Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer's Neuropathology in the APPSWE/PS1DE9 Mouse: A Novel Therapeutic Intervention for Alzheimer's Disease
Zhang J, Chen Y, Zhao Y, Wang P, Ding H, Liu C, Lyu J, Le W · 2024
Terahertz wave treatment significantly improved cognitive impairment and alleviated Alzheimer's neuropathology in a mouse model.
Plain English Summary
Researchers measured 0.14 THz wave penetration across mouse skulls and found approximately 70% penetration. They then exposed an Alzheimer's disease mouse model to repeated low-frequency terahertz waves on the head. The treatment significantly improved cognitive impairment and reduced amyloid-β deposition and tau hyperphosphorylation. It also attenuated mitochondrial impairment, neuroinflammation, and neuronal loss in the brain.
Why This Matters
The researchers noted that biological impacts of terahertz waves on the central nervous system were poorly investigated before this study. They concluded that terahertz waves may have potential as a novel therapeutic intervention for Alzheimer's disease.
Show BibTeX
@article{zhang_j_chen_y_zhao_y_wang_p_ding_h_liu_c_lyu_j_le_w_ce3582,
author = {Zhang J and Chen Y and Zhao Y and Wang P and Ding H and Liu C and Lyu J and Le W},
title = {Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer's Neuropathology in the APPSWE/PS1DE9 Mouse: A Novel Therapeutic Intervention for Alzheimer's Disease},
year = {2024},
}