Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis
Zhang X-J, Xiao Z-B, Gu J-X, Chen K, Wang J, Xu S-L, Xing K-K, Chen T · 2023
EMP exposure appears to alter gene expression networks involved in neurotransmitter synthesis and synaptic function, potentially explaining the observed behavioral and cognitive effects observed in the animal model.
Plain English Summary
This study investigated the molecular mechanisms underlying neuropsychiatric disorders induced by electromagnetic pulse (EMP) exposure in rats using bioinformatics analysis of gene expression data. The research identified 41 differentially expressed long noncoding RNAs and 266 differentially expressed messenger RNAs associated with EMP-induced anxiety, cognitive decline, and memory impairment, with particular involvement of neurotransmitter-related pathways and elevated serotonin, dopamine, and norepinephrine levels.
Why This Matters
This research employs high-throughput sequencing and network analysis to identify potential molecular pathways linking electromagnetic pulse exposure to neuropsychiatric effects. The study's focus on competing endogenous RNA (ceRNA) networks represents an approach to understanding complex gene regulation in response to physical stressors.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{zhang_x_j_xiao_z_b_gu_j_x_chen_k_wang_j_xu_s_l_xing_k_k_chen_t_ce4281,
author = {Zhang X-J and Xiao Z-B and Gu J-X and Chen K and Wang J and Xu S-L and Xing K-K and Chen T},
title = {Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis},
year = {2023},
doi = {10.1103/PhysRevLett.131.211902},
}