Isoflurane preconditioning ameliorates electromagnetic pulse-induced neural damage by shifting microglia polarization toward anti-inflammatory phenotype via upregulation of SOCS1
Zhang X, Lv M, Zhu X, Tian L, Li J, Shao Y, Gao C, Sun X · 2019
Isoflurane preconditioning reduced electromagnetic pulse-induced neural damage by shifting microglia to an anti-inflammatory state through SOCS1 upregulation.
Plain English Summary
Researchers exposed rats to electromagnetic pulse with or without isoflurane preconditioning and analyzed brain samples for microglia markers and inflammatory mediators. They also used SOCS1 siRNA in cultured microglia cells to test SOCS1's role. Electromagnetic pulse exposure made microglia pro-inflammatory, increased inflammatory cytokines and chemokines, activated the TLR4 pathway, and caused neuronal death. Isoflurane preconditioning reversed these changes and switched microglia to an anti-inflammatory phenotype. Blocking SOCS1 eliminated the protective effect of isoflurane preconditioning.
Why This Matters
The study notes that human exposure to electromagnetic fields has become increasingly common with technological advances. Electromagnetic field exposure may cause neural injuries and organ dysfunction, likely through neuroinflammation and microglial activation. Isoflurane preconditioning is known to provide neuroprotection in neurological diseases by inhibiting excessive neuroinflammatory responses.
Show BibTeX
@article{zhang_x_lv_m_zhu_x_tian_l_li_j_shao_y_gao_c_sun_x_ce4608,
author = {Zhang X and Lv M and Zhu X and Tian L and Li J and Shao Y and Gao C and Sun X},
title = {Isoflurane preconditioning ameliorates electromagnetic pulse-induced neural damage by shifting microglia polarization toward anti-inflammatory phenotype via upregulation of SOCS1},
year = {2019},
}