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Deep Brain Magnetic Stimulation Promotes Neurogenesis and Restores Cholinergic Activity in a Transgenic Mouse Model of Alzheimer's Disease

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Zhen J, Qian Y, Fu J, Su R, An H, Wang W , Zheng Y, Wang X · 2017

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Deep brain magnetic stimulation may have therapeutic potential for restoring neural function in Alzheimer's disease by promoting neuronal growth and acetylcholine system activity.

Plain English Summary

Summary written for general audiences

This study examined the effects of deep brain magnetic stimulation on neurogenesis and cholinergic activity in transgenic mice with Alzheimer's disease pathology. The research found that magnetic stimulation promoted neurogenesis and restored cholinergic activity in this disease model.

Why This Matters

This is a preclinical animal study using a transgenic mouse model, which is a standard first step for evaluating potential treatments before human trials. The focus on both neurogenesis and cholinergic restoration targets two relevant pathological features in Alzheimer's disease.

Exposure Information

Specific exposure levels were not quantified in this study.

Cite This Study
Zhen J, Qian Y, Fu J, Su R, An H, Wang W , Zheng Y, Wang X (2017). Deep Brain Magnetic Stimulation Promotes Neurogenesis and Restores Cholinergic Activity in a Transgenic Mouse Model of Alzheimer's Disease.
Show BibTeX
@article{zhen_j_qian_y_fu_j_su_r_an_h_wang_w_zheng_y_wang_x_ce4615,
  author = {Zhen J and Qian Y and Fu J and Su R and An H and Wang W  and Zheng Y and Wang X},
  title = {Deep Brain Magnetic Stimulation Promotes Neurogenesis and Restores Cholinergic Activity in a Transgenic Mouse Model of Alzheimer's Disease},
  year = {2017},
  doi = {10.1016/S0140-6736(17)32129-3},
  
}
DOI: 10.1016/S0140-6736(17)32129-3

Quick Questions About This Study

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