1950 MHz Electromagnetic Fields Ameliorate AB Pathology in Alzheimer's Disease Mice
Authors not listed · 2015
Chronic 1950 MHz RF-EMF exposure for eight months reduced amyloid plaques, APP fragments, and the Aβ42/Aβ40 ratio and rescued memory deficits in Tg-5xFAD mice.
Plain English Summary
Researchers exposed transgenic 5xFAD and wild-type mice to 1950 MHz RF-EMF for eight months at a SAR of 5 W/kg, two hours per day, five days per week. The exposure significantly reduced Aβ plaques, APP, and APP carboxyl-terminal fragments in the whole brain including hippocampus and entorhinal cortex, and reduced the Aβ42/Aβ40 ratio in the hippocampus of Tg-5xFAD mice. RF-EMF inhibited parenchymal BACE1 expression and neuroinflammation in the transgenic mice. The treatment rescued memory impairment in the transgenic mice. Gene profiling showed that five Aβ-related genes were significantly altered in transgenic mice, with opposite expression patterns compared with wild-type mice.
Why This Matters
The authors concluded that chronic RF-EMF exposure directly affects Aβ pathology in Alzheimer’s disease but not in normal brain. They suggested that RF-EMF has preventive effects against AD-like pathology in advanced AD mice with high Aβ expression, indicating a potential beneficial influence on AD.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{1950_mhz_electromagnetic_fields_ameliorate_ab_pathology_in_alzheimers_disease_mice_ce604,
author = {Unknown},
title = {1950 MHz Electromagnetic Fields Ameliorate AB Pathology in Alzheimer's Disease Mice},
year = {2015},
doi = {10.2174/156720501205150526114448},
}