Ikeda K, Nakamura K. · 2018
The cross-sectional study included 2,785 high school students in Niigata, Japan. Mean mobile phone use was 24 hours per week with a median of 18 hours. Longer mobile phone use was associated with female students, no sports club participation, early mobile phone use, and fewer hours of sleep. Overall associations between hours of mobile phone use and mood scores were significant for depressed mood, tension and excitement, and fatigue.
Gupta SK, Mesharam MK, Krishnamurthy S. · 2018
Male rats were exposed to EMR (900, 1800 and 2450 MHz) every day for 1 h for 28 consecutive days. Animals exposed to EMR-2450 MHz exhibited significant cognitive deficits. EMR-2450 MHz caused loss of mitochondrial function and integrity, an increase in amyloid beta expression. There was release of cytochrome-c and activation of apoptotic factors such as caspase-9 and -3 in the hippocampus. Further, there was decrease in levels of acetylcholine, and increase in activity of acetyl cholinesterase, indicating impairment of cholinergic system.
Zhang JP et al. · 2017
Researchers exposed adolescent male mice to a 1.8 GHz radiofrequency field for 4 weeks. Depression-like behavior, spatial memory ability, and brain histology did not change obviously after exposure. Anxiety-like behavior increased, and levels of GABA and aspartic acid in the cortex and hippocampus significantly decreased.
Sato Y, Kojimahara N, Taki M, Yamaguchi N · 2017
The study aimed to clarify the distribution of ear side of mobile phone use in Japan and factors associated with it. Statistically significant differences were observed only in talk time per call with an odds ratio of 2.17 and a 95% confidence interval of 1.22 to 3.99. In right-handed adults, left-ear use was significantly associated with age groups 30-39 (OR = 2.55; 95% CI: 1.79-3.68), 40-49 (OR = 3.08; 95% CI: 2.15-4.43), over 50 (OR = 1.85; 95% CI: 1.20-2.85), and with work-related talk time of 51-100% (OR = 1.75; 95% CI: 1.21-2.55). The survey included 2,518 children and 1,529 adults who completed an Internet-based survey, and data were analyzed by logistic regression. In children, the analysis focused on right-ear use in right-handed individuals due to dominant-hand tendency.
Durusoy R, Hassoy H, Özkurt A, Karababa AO. · 2017
Headache, fatigue, and sleep disturbances were reported 1.90, 1.78, and 1.53 times more often among mobile phone users. Dose-response relationships were found for call frequency, call duration, text message frequency, phone position at night, and charging while calling with symptoms such as headache, concentration difficulties, fatigue, sleep disturbances, ear warming, and flushing. No association was found between school EMF levels and symptoms, while limited associations were seen for proximity to base stations. Data were collected via questionnaire and EMF measurements from November 2009 to April 2011 using an Aaronia Spectran HF-4060 device.
Birks L et al. · 2017
Researchers analyzed data from 83,884 mother-child pairs across five birth cohorts in Denmark, Korea, the Netherlands, Norway, and Spain. They categorized maternal cell phone use during pregnancy into none, low, medium, and high based on call frequency reported by mothers. Child behavioral problems were assessed using the Strengths and Difficulties Questionnaire or Child Behavior Checklist at ages 5–7 years. A trend of increasing risk of hyperactivity/inattention problems was observed across cell phone use categories, with odds ratios of 1.11 for medium users and 1.28 for high users. The association was consistent across cohorts and between prospective and retrospective data collection methods.
Bhatt CR et al. · 2017
Altuntas G et al. · 2017
The study was a single-center, prospective, randomized, double-blinded trial involving 30 emergency physicians randomly assigned to two groups. The control group held a mobile phone in 'off' mode to their left ear for 15 minutes, while the intervention group held a phone in 'on' mode, exposing them to 900-1800 MHz electromagnetic waves for the same period. Total performance, total figures marked, percentile, and attention fluctuation did not differ between groups, but the intervention group missed fewer figures, made fewer incorrect marks, and showed better focus.
Varghese R, Majumdar A, Kumar G, Shukla A. · 2017
Researchers exposed female Sprague Dawley rats to 2.45GHz radiation for 4 hours per day for 45 days and assessed behavioral and oxidative stress parameters. Exposed rats exhibited memory decline and anxiety behavior in the Morris water maze, elevated plus maze, and light-dark box tests. Radiation exposure decreased brain antioxidant enzymes superoxide dismutase, catalase, and reduced glutathione, increased lipid peroxidation, and increased the apoptotic marker caspase 3, while histopathological examination and TNF-α levels showed no significant changes.
Othman H, Ammari M , Sakly M, Abdelmelek H. · 2017
Animals were divided into four groups: control, WiFi-exposed, restrained, and both WiFi-exposed and restrained, with each exposure occurring 2 h per day for 20 days. Tests included anxiety in the elevated plus maze, spatial learning in the water maze, cerebral oxidative stress response, and cholinesterase activity in brain and serum. WiFi exposure and restraint stress, alone and especially combined, induced anxiety-like behavior without impairing spatial learning and memory abilities. An oxidative stress response was triggered by WiFi and restraint, per se and especially when combined, as well as a WiFi-induced increase in acetylcholinesterase activity. There were no synergistic effects between WiFi signal and restraint stress on the brain.
Sharma A, Kesari KK, Saxena VK, Sisodia R. · 2017
Deniz OG et al. · 2017
Researchers studied 60 healthy female medical students divided into low (<30 min daily) and high (>90 min daily) mobile phone exposure groups. Hippocampal volume and metabolite levels did not differ significantly between groups. However, the high exposure group performed significantly worse on Stroop and digit span backward tests of attention.
Roser K et al. · 2017
Researchers measured personal RF-EMF exposure in 90 adolescents aged 13 to 17 years using a portable ExpoM-RF device across 13 frequency bands from 470 to 3600 MHz for three consecutive days with a time-activity diary. Mobile phones contributed 67.2% and mobile phone base stations contributed 19.8% of total personal RF-EMF measurements averaging 63.2 μW/m² (0.15 V/m). WLAN at school and home accounted for 3.5% of total personal measurements. Environmental sources contributed on average 6.0% to the brain dose and 9.0% to the whole-body dose according to dose calculations.
Wang K et al. · 2017
Researchers examined the effects of a single 30-minute exposure to 1.8 GHz radiofrequency electromagnetic radiation on recognition memory in mice, using the novel object recognition task. Exposure at an intensity above 2.2 W/kg SAR produced a significant, density-dependent increase in the recognition memory index, with no corresponding changes in spontaneous locomotor activity. The researchers also found that exposure increased dendritic-spine density and length in hippocampal and prefrontal cortical neurons, and significantly altered neuronal excitability in pyramidal neurons. The SAR used in the study was 3.3 W/kg, which the researchers noted was outside the range encountered in normal daily life.
Wang H et al. · 2017
Researchers exposed 220 male Wistar rats to a 2.856 GHz radiation source at power densities of 0, 2.5, 5, and 10 mW/cm² for 6 min/day, 5 days/week, for up to 6 weeks. Rats in the 10 mW/cm² group showed declines in spatial learning and memory and EEG disorders, including decreased EEG frequencies and increased amplitudes and delta wave powers. Changes in the basic structure and ultrastructure of the hippocampus were found in the 10 and 5 mW/cm² groups. The researchers suggested that continuous microwave exposure could cause dose-dependent long-term impairment of spatial learning and memory, and that decreases in NMDAR key subunits and phosphorylation of NR2B might contribute to cognitive impairment.
Son Y et al. · 2016
Researchers exposed 5xFAD mice to 1950 MHz RF-EMF at 5 W/kg SAR for 2 hours daily, 5 days a week, for 3 months. They used Y-maze, Morris water maze, and novel object recognition tests to assess spatial and non-spatial memory. They also measured Aβ deposition, APP and CTFβ levels in hippocampus and cortex, and plasma Aβ peptides. The 3-month exposure did not affect Aβ-related memory impairment or Aβ accumulation.
Roser K, Schoeni A, Röösli M · 2016
The HERMES study sample consisted of 439 Swiss adolescents aged 12–17 years. Researchers assessed behavioral problems with the Strengths and Difficulties Questionnaire and concentration capacity with a standardized computerized cognitive test named FAKT. Cross-sectional analyses showed behavioral problems associated with self-reported wireless device use but not operator-recorded mobile phone use, while concentration capacity was associated with both self-reported and operator-recorded exposures. Longitudinal analyses found no consistent associations between RF-EMF exposure measures and either outcome. The authors suggest information bias and reverse causality likely explain the cross-sectional findings.
Redmayne M et al. · 2016
Researchers recruited 619 fourth-grade students aged 8 to 11 from 37 schools in Melbourne and Wollongong, Australia. Participants completed a questionnaire, a computerised cognitive test battery, and the Stroop colour-word test while parents reported the children's mobile and cordless phone call frequencies. Phone use was categorised by weekly call count into none, some (≤ median) or more (> median), with medians of 2.5 calls for mobile phones and 2.0 for cordless phones. Only 5 of 78 comparisons were statistically significant; higher mobile phone use was linked to slower reaction time on a response-inhibition task, and higher cordless phone use was linked to slower Stroop interference time and poorer accuracy on visual recognition, episodic memory, and identification tasks.
Calvente I et al. · 2016
Choi Y-J, Choi Y-S · 2016
Male mice were exposed for 9 weeks and female mice for 11 weeks to smartphone electromagnetic radiation. Spatial working memory was tested with a Y maze and hippocampal progenitor cell proliferation was measured using BrdU labeling. After 9 weeks there was no significant difference in spontaneous alternation scores or hippocampal progenitor cell proliferation between exposed and control mice.
Bouji M, Lecomte A, Gamez C, Blazy K, Villégier AS. · 2016
Researchers exposed aged (22–24 months) and young (4–6 months) adult male rats to head RF-EMF exposures at 900 MHz, with a specific absorption rate of 6 W/kg, for 45 minutes per day for 1 month. Aged rats showed deficits in spatial learning, exploration, anxiety-related behaviors, and increased hippocampal ILs and cortical IL-1β. The senescence-typical neurobiological deficits were not modified by RF-EMF exposures, and the study did not support the hypothesis of a specific cerebral vulnerability to RF-EMF during senescence. RF-EMF-exposed rats, with young and aged adults pooled, had decreased anxiety-related behaviors in the elevated plus maze.
Wang LF et al. · 2016
Researchers exposed Wistar rats to microwave radiation at 30 mW/cm2 for 5 minutes per day, 5 days per week, over a period of 2 months. Screening of the GRIN2B promoter region revealed a stable C-to-T variant at nucleotide position −217 that was not induced by microwave exposure. Following microwave exposure, NR2B protein expression decreased, while the Glu contents in the hippocampus and CSF increased, and memory impairment was observed in the TT genotype but not the CC and CT genotypes. In PC12 cells, the effects of the T allele were more pronounced than those of the C allele on transcription factor binding ability, transcriptional activity, NR2B mRNA, and protein expression.
Deshmukh PS et al. · 2016
Researchers exposed male Fischer rats to microwave radiation for 90 days at 900, 1800, and 2450 MHz to investigate effects on cognitive function, heat shock protein 70 (HSP70) levels, and DNA damage in the brain. Cognitive function was tested using the elevated plus maze and Morris water maze, HSP70 levels were measured by ELISA, and DNA damage was assessed using alkaline comet assay. The results suggest that low-level microwave exposure at these frequencies may lead to hazardous effects on the brain.
(E) Barthélémy A et al. · 2016
Researchers exposed male Sprague Dawley rats for 15 minutes at 0, 1.5, or 6 W/kg, or for 45 minutes at 6 W/kg, to radiofrequency electromagnetic fields. Memory, emotionality, and locomotion were tested using fear conditioning, the elevated plus maze, and the open field. Long-term memory was reduced and cytosolic GFAP was increased in the hippocampus and in the olfactory bulb at 6 W/kg. No MBP or Aβ1–40 expression modification was shown. The study suggests that RF EMF-induced astrogliosis had functional consequences on memory but did not demonstrate that it was secondary to neuronal damage.
Schoeni A, Roser K, Röösli M. · 2015
In a cross-sectional study, 439 adolescents completed questionnaires about mobile phone use at night and health, and 233 provided operator-recorded use data. Standardized computerized cognitive tests assessed memory and concentration capacity. Adolescents who reported being awakened at least once a month had higher odds of daytime tiredness (OR 1.86) and rapid exhaustibility (OR 2.28). Similar associations were seen with objective operator-recorded data for tiredness (OR 1.63) and rapid exhaustibility (OR 2.32). Cognitive test performance was not related to nighttime mobile phone use.
