50 Hz Magnetic Field Exposure Inhibited Spontaneous Movement of Zebrafish Larvae through ROS-Mediated syn2a Expression
Guo, Y., FU, Y, Sun W. 50 Hz Magnetic Field Exposure Inhibited Spontaneous Movement of Zebrafish Larvae through ROS-Mediated syn2a Expression. Int. J. · 2023
Exposure to a 50-Hz magnetic field inhibited spontaneous movement of zebrafish larvae through ROS-mediated syn2a expression in a nonlinear manner.
Plain English Summary
Researchers exposed zebrafish embryos at 3 hours post-fertilization to a 50-Hz magnetic field at intensities of 100, 200, 400, and 800 μT for 1 hour or 24 hours daily over 5 days. Magnetic field exposure did not affect basic development parameters including hatching rate, mortality, and malformation rate. Exposure to 200 μT magnetic field significantly induced spontaneous movement hypoactivity in zebrafish larvae. Histological examination revealed brain morphological abnormalities including condensed cell nucleus and cytoplasm and increased intercellular space. Exposure to 200 μT magnetic field inhibited syn2a transcription and expression and increased reactive oxygen species levels.
Why This Matters
Overexpression of syn2a effectively rescued the magnetic field-induced spontaneous movement hypoactivity. Pretreatment with N-acetyl-L-cysteine recovered syn2a protein expression weakened by magnetic field exposure and abolished the induced hypoactivity. However, syn2a overexpression did not affect the magnetic field-induced increase in reactive oxygen species.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{50_hz_magnetic_field_exposure_inhibited_spontaneous_movement_of_zebrafish_larvae_through_ros_mediated_syn2a_expression_ce4043,
author = {Guo and Y. and FU and Y and Sun W. 50 Hz Magnetic Field Exposure Inhibited Spontaneous Movement of Zebrafish Larvae through ROS-Mediated syn2a Expression. Int. J.},
title = {50 Hz Magnetic Field Exposure Inhibited Spontaneous Movement of Zebrafish Larvae through ROS-Mediated syn2a Expression},
year = {2023},
doi = {10.3390/ijms24087576},
}