6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
Shield Your Body
Oxidative Stress

Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin

Bioeffects Seen

Ayata A, Mollaoglu H, Yilmaz HR, Akturk O, Ozguner F, Altuntas I · 2004

View Original Abstract
Share:

The results suggest that rats irradiated with 900 MHz suffer from increased fibrosis and lipid peroxidation, and melatonin treatment can reduce these effects.

Plain English Summary

Summary written for general audiences

Thirty Wistar-Albino rats were assigned to control, irradiated, and irradiated-plus-melatonin groups, and the irradiated group received 900 MHz, 2 W radiation for 30 minutes daily over 10 days. The melatonin group received 10 mg/kg/day melatonin in tap water for 10 days before irradiation. Skin samples were analyzed for malondialdehyde, hydroxyproline, superoxide dismutase, glutathione peroxidase, and catalase. Radiation significantly increased MDA, hydroxyproline, CAT, and GSH-Px and decreased SOD; melatonin reversed the increases in MDA, hydroxyproline, CAT, and GSH-Px but did not prevent the SOD decrease. The results suggest that 900 MHz radiation increases fibrosis and lipid peroxidation in rat skin and that melatonin can reduce these effects.

Why This Matters

The study aimed to evaluate how 900 MHz radiation affects fibrosis, lipid peroxidation, and antioxidant enzymes in rat skin and whether melatonin can ameliorate these effects. Skin specimens were collected from the thoracoabdominal area at the end of the 10-day exposure period.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900 MHz Duration: Every day for 10 days (30 min/day)

Study Details

The effects of 900 MHz of radiation on fibrosis, lipid peroxidation, and antioxidant enzymes and the ameliorating effects of melatonin (Mel) were evaluated in rat skin.

Thirty Wistar-Albino rats were used in the study. The experimental groups were the control group, th...

MDA and hydroxyproline levels and activities of CAT and GSH-Px were increased significantly in the I...

These results suggest that rats irradiated with 900 MHz suffer from increased fibrosis and lipid peroxidation (LPO). Mel treatment can reduce the fibrosis and LPO caused by radiation.

Cite This Study
Ayata A, Mollaoglu H, Yilmaz HR, Akturk O, Ozguner F, Altuntas I (2004). Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin J Dermatol. 31(11):878-883, 2004.
Show BibTeX
@article{a_2004_oxidative_stressmediated_skin_damage_1612,
  author = {Ayata A and Mollaoglu H and Yilmaz HR and Akturk O and Ozguner F and Altuntas I},
  title = {Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin},
  year = {2004},
  doi = {10.1111/j.1346-8138.2004.tb00620.x},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1346-8138.2004.tb00620.x},
}
DOI: 10.1111/j.1346-8138.2004.tb00620.x

Cited By (60 papers)

View all 60 citing papers on Semantic Scholar

Quick Questions About This Study

The irradiated rats received 900 MHz, 2 W radiation for 30 minutes each day for 10 days.
The study measured malondialdehyde, hydroxyproline, superoxide dismutase, glutathione peroxidase, and catalase in skin samples.
Melatonin significantly decreased the elevated MDA, hydroxyproline, CAT, and GSH-Px levels caused by radiation.
Radiation significantly decreased SOD activity, and melatonin did not prevent this decrease.
The authors suggest that 900 MHz radiation increases fibrosis and lipid peroxidation in rat skin and that melatonin can reduce these effects.