Effects of extremely low-frequency magnetic field in the brain of rats
Jelenković A, Janać B, Pesić V, Jovanović DM, Vasiljević I, Prolić Z. · 2006
View Original AbstractA 7-day exposure to a 50 Hz, 0.5 mT magnetic field significantly increased superoxide radicals in all brain regions examined in adult male rats.
Plain English Summary
Researchers exposed adult male Wistar rats to a 50 Hz, 0.5 mT extremely low-frequency magnetic field for 7 days, while control rats were sham-exposed. Superoxide dismutase activities and production of superoxide radicals, lipid peroxidation, and nitric oxide were examined in the frontal cortex, striatum, basal forebrain, hippocampus, brainstem, and cerebellum. Superoxide radicals were significantly increased in all regions examined, and lipid peroxidation was significantly increased in the basal forebrain and frontal cortex. The researchers indicated that the 7-day exposure can be harmful to the brain, especially to the basal forebrain and frontal cortex due to development of lipid peroxidation.
Why This Matters
Nitric oxide production was significantly increased in some brain structures, specifically the frontal cortex, basal forebrain, hippocampus, and brainstem. Lipid peroxidation still rose significantly in the basal forebrain and frontal cortex, in spite of the significantly increased superoxide dismutase activities and nitric oxide production in the basal forebrain, and increased production of nitric oxide in the frontal cortex. The researchers suggested that high production of superoxide anion in all regions may compromise nitric oxide signaling processes, due to nitric oxide consumption in the reaction with the superoxide radical.
Exposure Details
- Magnetic Field
- 0.5 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 7-day
Exposure Context
This study used 0.5 mT for magnetic fields:
- 25Kx above the Building Biology guideline of 0.2 mG
- 5Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
An extremely low-frequency magnetic field (50 Hz, 0.5 mT) was used to investigate its possible effect on the brain of adult male Wistar rats following a 7-day exposure.
The control rats were sham-exposed. Superoxide dismutase activities and production of superoxide rad...
Significantly increased superoxide radical contents were registered in all the structures examined. ...
Show BibTeX
@article{a_2006_effects_of_extremely_lowfrequency_391,
author = {Jelenković A and Janać B and Pesić V and Jovanović DM and Vasiljević I and Prolić Z.},
title = {Effects of extremely low-frequency magnetic field in the brain of rats},
year = {2006},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0361923005003977},
}