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Modest increase in temperature affects ODC activity in L929 cells: low-level radiofrequency radiation does not.

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Hoyto A, Sihvonen AP, Alhonen L, Juutilainen J, Naarala J · 2006

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Low-level RF radiation did not affect ODC activity in L929 cells, but a slight temperature rise of 0.8-0.9 degrees C decreased it.

Plain English Summary

Summary written for general audiences

Researchers investigated the effects of low-level radiofrequency radiation and elevated temperature on ornithine decarboxylase (ODC) activity in murine L929 fibroblasts. RF radiation did not affect cellular ODC activity. A slight temperature increase of 0.8-0.9 degrees C in the exposure system led to decreased ODC activity, which was verified by exposing cells to different temperatures in incubators.

Why This Matters

The cells were exposed at 900 MHz to either a pulse-modulated signal with a pulse frequency of 217 Hz and GSM-type modulation, or a continuous wave signal. SAR levels were 0.2 W kg(-1) and 0.4 W kg(-1), and exposures lasted 2, 8, or 24 h. The researchers concluded that ODC activity is sensitive to small temperature differences in cell cultures, and that precise temperature control is needed in such studies.

Exposure Details

SAR
0.1-0.3, 0.3-0.5 W/kg
Source/Device
900 MHz
Exposure Duration
2, 8, or 24 hours

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.1-0.3, 0.3-0.5 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 16 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The effects of low-level radiofrequency (RF) radiation and elevated temperature on ornithine decarboxylase (ODC) activity were investigated in murine L929 fibroblasts

The cells were exposed at 900 MHz either to a pulse-modulated (pulse frequency 217 Hz; GSM-type modu...

RF radiation did not affect cellular ODC activity. However, a slight increase in temperature (0.8-0....

The results show that ODC activity is sensitive to small temperature differences in cell cultures. Hence, a precise temperature control in cellular ODC activity studies is needed.

Cite This Study
Hoyto A, Sihvonen AP, Alhonen L, Juutilainen J, Naarala J (2006). Modest increase in temperature affects ODC activity in L929 cells: low-level radiofrequency radiation does not. Radiat Environ Biophys.45(3):231-235, 2006.
Show BibTeX
@article{a_2006_modest_increase_in_temperature_1032,
  author = {Hoyto A and Sihvonen AP and Alhonen L and Juutilainen J and Naarala J},
  title = {Modest increase in temperature affects ODC activity in L929 cells: low-level radiofrequency radiation does not.},
  year = {2006},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/16850337/},
}
PubMed: 16850337

Cited By (23 papers)

Quick Questions About This Study

RF radiation did not affect cellular ODC activity in the study.
A slight increase in temperature of 0.8-0.9 degrees C led to decreased ODC activity in cell cultures.
The study used murine L929 fibroblasts, and examined ornithine decarboxylase (ODC) activity in those cells.
The results show that ODC activity is sensitive to small temperature differences in cell cultures, and the researchers stated that precise temperature control in cellular ODC activity studies is needed.