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DNA & Genetic Damage

No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal

No Effects Found

Paparini A, Rossi P, Gianfranceschi G, Brugaletta V, Falsaperla R, De Luca P, Romano Spica V. · 2008

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No consistent gene expression changes were found in mouse brain after GSM 1800 MHz exposure.

Plain English Summary

Summary written for general audiences

Mice were exposed to GSM 1800 MHz signal for 1 hour at a whole body SAR of 1.1 W/kg. Gene expression was measured in whole brain using microarrays with over 22,600 probe sets. Comparison of sham and exposed animals showed no significant difference in gene expression. With less stringent analysis, 75 genes appeared modulated but were not confirmed by real-time PCR.

Exposure Details

SAR
1.1 W/kg
Source/Device
1800 MHz GSM
Exposure Duration
1h
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

To analyze possible effects of microwaves on gene expression, mice were exposed to global system for mobile communication (GSM) 1800 MHz signal for 1 h at a whole body SAR of 1.1 W/kg.

Gene expression was studied in the whole brain, where the average SAR was 0.2 W/kg, by expression mi...

However, when less stringent constraints were adopted to analyze microarray results, 75 genes were f...

Under these specific limited conditions, no consistent indication of gene expression modulation in whole mouse brain was found associated to GSM 1800 MHz exposure.

Cite This Study
Paparini A, Rossi P, Gianfranceschi G, Brugaletta V, Falsaperla R, De Luca P, Romano Spica V. (2008). No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal Bioelectromagnetics. 29(4):312-323, 2008.
Show BibTeX
@article{a_2008_no_evidence_of_major_2792,
  author = {Paparini A and Rossi P and Gianfranceschi G and Brugaletta V and Falsaperla R and De Luca P and Romano Spica V.},
  title = {No evidence of major transcriptional changes in the brain of mice exposed to 1800 MHz GSM signal},
  year = {2008},
  doi = {10.1002/bem.20399},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.20399},
}
DOI: 10.1002/bem.20399

Cited By (41 papers)

Quick Questions About This Study

Mice were exposed to GSM 1800 MHz signal for 1 hour at a whole body SAR of 1.1 W/kg.
No significant difference in gene expression was found between sham and exposed mice.
Seventy-five genes appeared modulated with less stringent criteria, but these changes were not confirmed by real-time PCR.
The average SAR in the whole brain was 0.2 W/kg.
Expression microarrays containing over 22,600 probe sets were used to study gene expression in the whole brain.