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Enhancement of Cortical Network Activity in vitro and Promotion of GABAergic Neurogenesis by Stimulation with an Electromagnetic Field with a 150 MHz Carrier Wave Pulsed with an Alternating 10 and 16 Hz Modulation.

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Gramowski-Voß A, Schwertle HJ, Pielka AM, Schultz L, Steder A, Jügelt K, Axmann J, Pries W5. · 2015

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Exposure to a 150 MHz carrier wave pulsed at alternating 10 and 16 Hz accelerated cortical network development and increased the proportion of GABAergic neurons in murine cortical cultures.

Plain English Summary

Summary written for general audiences

Researchers exposed differentiating murine cortical networks on multiwell microelectrode arrays to an extremely low-frequency electromagnetic field with alternating 10 and 16 Hz modulation on a 150 MHz carrier. The development of cortical activity was accelerated under these exposure conditions. The percentage of neurons in the co-culture increased without changing the total cell count, indicating enhanced neurogenesis. ELEMF exposure selectively promoted the proliferation of GABAergic neurons, increasing their proportion. The exposure also stimulated electrical network activity and intensified burst structure.

Why This Matters

The results supported the hypothesis that this ELEMF stimulation could be a treatment option for CNS applications, especially for degenerative diseases such as Alzheimer's disease and other dementias. Exposure within the first 28 days in vitro induced reorganization within the burst structure, with the effect most pronounced at 14 days in vitro after 10 days of exposure.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 16 Hz - 150 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 16 Hz - 150 MHzPower lines50/60 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 10 and 16 Hz piggy backed onto a 150 MHz Duration: 10 Days

Study Details

In this study, differentiating murine cortical networks on multiwell microelectrode arrays were repeatedly exposed to an extremely low-electromagnetic field (ELEMF) with alternating 10 and 16 Hz frequencies piggy backed onto a 150 MHz carrier frequency.

The ELEMF exposure stimulated the electrical network activity and intensified the structure of burst...

Overall, the development of cortical activity under these conditions was accelerated. These function...

The results support the initial hypothesis that this kind of ELEMF stimulation could be a treatment option for specific indications with promising potential for CNS applications, especially for degenerative diseases, such as Alzheimer's disease and other dementias.

Cite This Study
Gramowski-Voß A, Schwertle HJ, Pielka AM, Schultz L, Steder A, Jügelt K, Axmann J, Pries W5. (2015). Enhancement of Cortical Network Activity in vitro and Promotion of GABAergic Neurogenesis by Stimulation with an Electromagnetic Field with a 150 MHz Carrier Wave Pulsed with an Alternating 10 and 16 Hz Modulation. Front Neurol. 2015 Jul 14;6:158. doi: 10.3389/fneur.2015.00158. eCollection 2015.
Show BibTeX
@article{a_2015_enhancement_of_cortical_network_2121,
  author = {Gramowski-Voß A and Schwertle HJ and Pielka AM and Schultz L and Steder A and Jügelt K and Axmann J and Pries W5.},
  title = {Enhancement of Cortical Network Activity in vitro and Promotion of GABAergic Neurogenesis by Stimulation with an Electromagnetic Field with a 150 MHz Carrier Wave Pulsed with an Alternating 10 and 16 Hz Modulation.},
  year = {2015},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/26236278/},
}
PubMed: 26236278

Cited By (23 papers)

Quick Questions About This Study

The study used an extremely low-frequency electromagnetic field with alternating 10 and 16 Hz modulation on a 150 MHz carrier wave.
The development of cortical activity was accelerated.
The percentage of neurons increased without affecting the total number of cells, indicating enhanced neurogenesis.
The exposure selectively promoted the proliferation of GABAergic neurons, increasing their proportion.
The results support the hypothesis that this ELEMF stimulation could be a treatment option for CNS applications, especially for degenerative diseases like Alzheimer's disease and other dementias.