Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson's disease.
Dileone M, Carrasco-López MC, Segundo-Rodriguez JC, Mordillo-Mateos L, López-Ariztegui N, Alonso-Frech F, Catalan-Alonso MJ, Obeso JA, Oliviero A, Foffani G, · 2017
View Original AbstracttSMS significantly decreased MEP amplitudes in patients off medication but not on medication, suggesting dopamine-dependent changes in cortical excitability.
Plain English Summary
Researchers performed a randomized double-blind sham-controlled cross-over study applying tSMS for 10 minutes to the more affected motor cortex of Parkinson's disease patients. Cortical excitability was measured by motor evoked potential amplitude elicited by single-pulse transcranial magnetic stimulation. tSMS significantly decreased MEP amplitudes in patients off dopaminergic medication but not in patients on levodopa. Between-patient variability of tSMS-induced changes was significantly greater when patients were on medication. Greater disease progression was associated with a switch from inhibitory to facilitatory plasticity on medication.
Why This Matters
The study aimed to test whether tSMS could modulate cortical excitability in Parkinson's disease patients. The results suggest that tSMS induces dopamine-dependent changes of cortical excitability in patients with Parkinson’s disease.
Exposure Information
Specific exposure levels were not quantified in this study. Duration: 10 min
Study Details
The objective of the present study was to test the ability of tSMS to modulate cortical excitability in patients with Parkinson’s disease.
We performed a randomized double-blind sham-controlled cross-over study to assess cortical excitabil...
tSMS significantly decreased MEP amplitudes in patients OFF medication (after overnight withdrawal o...
These results suggest that tSMS induces dopamine-dependent changes of cortical excitability in patients with Parkinson’s disease.
Show BibTeX
@article{m_2017_dopaminedependent_changes_of_cortical_1738,
author = {Dileone M and Carrasco-López MC and Segundo-Rodriguez JC and Mordillo-Mateos L and López-Ariztegui N and Alonso-Frech F and Catalan-Alonso MJ and Obeso JA and Oliviero A and Foffani G and},
title = {Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson's disease.},
year = {2017},
url = {https://www.nature.com/articles/s41598-017-04254-y},
}