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Protective effects of β-glucan against oxidative injury induced by 2.45-GHz electromagnetic radiation in the skin tissue of rats

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Ceyhan AM, Akkaya VB, Güleçol ŞC, Ceyhan BM, Özgüner F, Chen W · 2012

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Exposure to 2.45-GHz radiation increased malondialdehyde and catalase activity while decreasing superoxide dismutase and glutathione peroxidase in rat skin, and β-glucan significantly reversed the malondialdehyde rise and the superoxide dismutase drop.

Plain English Summary

Summary written for general audiences

Thirty-two male Wistar albino rats were divided into control, sham, electromagnetic radiation, and radiation plus β-glucan groups. Rats in the radiation groups were exposed to a 2.45-GHz field for 60 minutes daily over four weeks, and β-glucan was given at 50 mg/kg/day by gavage before each exposure. Radiation increased malondialdehyde and catalase activity and decreased superoxide dismutase and glutathione peroxidase activities, while β-glucan significantly reversed the malondialdehyde rise and the superoxide dismutase drop, with non-significant effects on catalase and glutathione peroxidase.

Why This Matters

The study aimed to investigate how 2.45-GHz electromagnetic radiation affects the oxidant and antioxidant status of skin and whether β-glucan can protect against oxidative injury. The authors concluded that oxidative mechanisms underlie radiation-induced skin damage and that β-glucan can ameliorate this injury through its antioxidant properties.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 2.45-GHz Duration: 60 min daily, respectively, for 4 weeks.

Study Details

The aim of the present study was to investigate the effect of 2.45-GHz electromagnetic radiation (EMR) on the oxidant and antioxidant status of skin and to examine the possible protective effects of β-glucans against the oxidative injury.

Thirty-two male Wistar albino rats were randomly divided into four equal groups: control; sham expos...

Exposure to 2.45-GHz EMR caused a significant increase in MDA levels and CAT activity, while the act...

The present study demonstrated the role of oxidative mechanisms in EMR-induced skin tissue damages and that β-glucan could ameliorate oxidative skin injury via its antioxidant properties.

Cite This Study
Ceyhan AM, Akkaya VB, Güleçol ŞC, Ceyhan BM, Özgüner F, Chen W (2012). Protective effects of β-glucan against oxidative injury induced by 2.45-GHz electromagnetic radiation in the skin tissue of rats Arch Dermatol Res. 304(7):521-527, 2012.
Show BibTeX
@article{am_2012_protective_effects_of_glucan_1624,
  author = {Ceyhan AM and Akkaya VB and Güleçol ŞC and Ceyhan BM and Özgüner F and Chen W},
  title = {Protective effects of β-glucan against oxidative injury induced by 2.45-GHz electromagnetic radiation in the skin tissue of rats},
  year = {2012},
  doi = {10.1007/s00403-012-1205-9},
  url = {https://link.springer.com/article/10.1007/s00403-012-1205-9},
}
DOI: 10.1007/s00403-012-1205-9

Cited By (31 papers)

Quick Questions About This Study

Rats were exposed to a 2.45-GHz electromagnetic field for 60 minutes each day for four weeks.
β-glucan was administered by gavage at 50 mg/kg/day before each radiation exposure.
Radiation significantly increased malondialdehyde and catalase activity while decreasing superoxide dismutase and glutathione peroxidase activities.
β-glucan significantly reversed the increase in malondialdehyde and the decrease in superoxide dismutase, with non-significant effects on catalase and glutathione peroxidase.