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Oxidative Stress

In vitro non-thermal oxidative stress response after 1800 MHz radiofrequency radiation.

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Marjanovic Cermak AM, Pavicic I, Tariba Lovakovic B, Pizent A, Trosic I · 2017

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Short-term 1800 MHz RF exposure produced a transient oxidation-reduction imbalance in fibroblast cells, without affecting cell viability or causing lipid oxidative damage.

Plain English Summary

Summary written for general audiences

Researchers exposed V79 fibroblast cells to 1800 MHz RF radiation for 10, 30, and 60 minutes at a specific absorption rate of 1.6 W/kg to investigate possible links between radiofrequency exposure and oxidative stress. Cell viability remained within normal physiological values regardless of exposure time. An increased level of superoxide radicals was detected after 60-minute exposure, and a significantly higher GSH level was observed immediately after 10-minute exposure, though GSH-Px activity was higher but not significant. Lipid oxidative damage in exposed cell samples was not observed.

Why This Matters

The study measured several markers of oxidative stress, including reactive oxygen species, the antioxidant molecule glutathione (GSH), the enzyme glutathione peroxidase (GSH-Px), and malondialdehyde as a marker of lipid damage. The electromagnetic field was generated within a Gigahertz Transversal Electromagnetic Mode cell equipped with a signal generator, amplifier, and modulator, with an electric field strength of 30 V/m. The oxidative changes observed were described as transient, with the cells showing adaptation to the experimental conditions. The significantly elevated GSH appeared after 10-minute exposure, while increased superoxide radicals appeared only after 60-minute exposure, suggesting the response varied with exposure duration.

Exposure Details

SAR
1.6 W/kg
Electric Field
30 V/m
Source/Device
1800 MHz
Exposure Duration
10, 30 and 60 minutes

Exposure Context

This study used 30 V/m for electric fields:

This study used 1.6 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1.6 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

In this study possible connection between radiofrequency exposure (RF) and development of oxidative stress was investigated by measuring impairment in cellular oxidation-reduction balance immediately after RF exposure

Fibroblast cells V79 were exposed for 10, 30 and 60 minutes to 1800 MHz RF radiation. Electric field...

Viability of V79 cells remained within normal physiological values regardless of exposure time. Incr...

Short-term RF exposure revealed transient oxidation-reduction imbalance in fibroblast cells following adaptation to applied experimental conditions

Cite This Study
Marjanovic Cermak AM, Pavicic I, Tariba Lovakovic B, Pizent A, Trosic I (2017). In vitro non-thermal oxidative stress response after 1800 MHz radiofrequency radiation. Gen Physiol Biophys. 36(4): 407-414, 2017.
Show BibTeX
@article{am_2017_in_vitro_nonthermal_oxidative_551,
  author = {Marjanovic Cermak AM and Pavicic I and Tariba Lovakovic B and Pizent A and Trosic I},
  title = {In vitro non-thermal oxidative stress response after 1800 MHz radiofrequency radiation.},
  year = {2017},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/28836500/},
}
PubMed: 28836500

Cited By (12 papers)

Quick Questions About This Study

Cell viability remained within normal physiological values regardless of exposure time.
Lipid oxidative damage in exposed cell samples was not observed.
An increased level of superoxide radicals was detected after 60-minute exposure.
V79 fibroblast cells were exposed to 1800 MHz RF radiation for 10, 30, and 60 minutes.
The researchers described the changes as a transient oxidation-reduction imbalance in fibroblast cells following adaptation to the applied experimental conditions.