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Oxidative Stress

Oxidative stress response in SH-SY5Y cells exposed to short-term 1800 MHz radiofrequency radiation

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Marjanovic Cermak AM, Pavicic I, Trosic I · 2017

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The results of the study showed enhanced susceptibility of SH-SY5Y cells for development of oxidative stress even after short-term RF exposure.

Plain English Summary

Summary written for general audiences

Human neuroblastoma SH-SY5Y cells were exposed to 1800 MHz radiofrequency radiation for 10, 30, and 60 minutes at an electric field strength of 30 V m-1 and a specific absorption rate of 1.6 W kg-1. Cell viability remained within normal physiological values after radiation exposure. Significantly higher ROS levels were observed at every radiation exposure time tested. After 60 minutes of exposure, the radiation caused significant lipid and protein damage. The highest glutathione concentration was detected after 10 minutes of exposure.

Why This Matters

The study aimed to investigate the oxidative stress response in SH-SY5Y cells exposed to short-term 1800 MHz radiofrequency radiation. Researchers measured viability with an MTT assay, ROS with a fluorescent probe, lipid and protein damage via malondialdehyde and protein carbonyls, and antioxidant activity via total glutathione. The authors concluded that SH-SY5Y cells have enhanced susceptibility to oxidative stress from short-term RF exposure.

Exposure Details

SAR
1.6 W/kg
Electric Field
30 V/m
Source/Device
1800 MHz
Exposure Duration
10, 30 and 60 minutes

Exposure Context

This study used 30 V/m for electric fields:

This study used 1.6 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1.6 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.80 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.80 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

To investigate the oxidative stress response in SH-SY5Y cells exposed to short-term 1800 MHz radiofrequency radiation.

To test the proposed hypothesis, human neuroblastoma cells (SH-SY5Y) were exposed to 1800 MHz short-...

After radiation exposure, viability of irradiated cells remained within normal physiological values....

The results of our study showed enhanced susceptibility of SH-SY5Y cells for development of oxidative stress even after short-term RF exposure.

Cite This Study
Marjanovic Cermak AM, Pavicic I, Trosic I (2017). Oxidative stress response in SH-SY5Y cells exposed to short-term 1800 MHz radiofrequency radiation J Environ Sci Health A Tox Hazard Subst Environ Eng. 2017 Nov 17:1-7. doi: 10.1080/10934529.2017.1383124.
Show BibTeX
@article{am_2017_oxidative_stress_response_in_1184,
  author = {Marjanovic Cermak AM and Pavicic I and Trosic I},
  title = {Oxidative stress response in SH-SY5Y cells exposed to short-term 1800 MHz radiofrequency radiation},
  year = {2017},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/29148897/},
}
PubMed: 29148897

Cited By (29 papers)

Quick Questions About This Study

Human neuroblastoma SH-SY5Y cells were exposed to 1800 MHz radiofrequency radiation for 10, 30, and 60 minutes at an electric field strength of 30 V m-1 and a specific absorption rate of 1.6 W kg-1.
Cell viability remained within normal physiological values after radiation exposure.
Significantly higher ROS levels were observed at every radiation exposure time tested.
After 60 minutes of exposure, the radiation caused significant lipid and protein damage.
The highest glutathione concentration was detected after 10 minutes of exposure.