Neuroprotective effects of sevoflurane against electromagnetic pulse-induced brain injury through inhibition of neuronal oxidative stress and apoptosis.
Deng B, Xu H, Zhang J, Wang J, Han LC, Li LY, Wu GL, Hou YN, Guo GZ, Wang Q, Sang HF, Xu LX. · 2014
View Original AbstractSevoflurane showed neuroprotective effects against electromagnetic pulse-induced brain damage in rats by inhibiting oxidative stress and apoptosis.
Plain English Summary
Researchers investigated the effects of sevoflurane on brain injury caused by electromagnetic pulse (EMP) exposure in rats and in cultured neurons. Rats were exposed to EMP and immediately treated with sevoflurane, and their brain tissue and behavior were assessed. Sevoflurane alleviated neuronal abnormalities in the cerebral cortex and reduced learning and memory deficits caused by EMP exposure. In cell experiments, EMP exposure reduced cell viability and increased LDH release, and sevoflurane treatment ameliorated these effects.
Why This Matters
The study used both an animal model and cultured primary cerebral cortical neurons to test whether sevoflurane could protect against EMP-related brain damage. Behavioral effects in the rats were measured using the open-field test and the Morris water maze. Oxidative stress was measured by SOD activity and MDA levels, and sevoflurane increased SOD activity and decreased MDA levels. Neuronal apoptosis was assessed with TUNEL staining and apoptotic markers, and sevoflurane was found to alleviate apoptosis by regulating the expression of cleaved caspase-3, Bax and Bcl-2.
Exposure Details
- Electric Field
- 400000 V/m
Exposure Context
This study used 400000 V/m for electric fields:
- 1.3Mx above the Building Biology guideline of 0.3 V/m
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Study Details
We investigated the effects of sevoflurane on EMP-induced brain injury.
Rats were exposed to EMP and immediately treated with sevoflurane. The protective effects of sevoflu...
The cerebral cortexes of EMP-exposed rats presented neuronal abnormalities. Sevoflurane alleviated t...
These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.
Show BibTeX
@article{b_2014_neuroprotective_effects_of_sevoflurane_344,
author = {Deng B and Xu H and Zhang J and Wang J and Han LC and Li LY and Wu GL and Hou YN and Guo GZ and Wang Q and Sang HF and Xu LX.},
title = {Neuroprotective effects of sevoflurane against electromagnetic pulse-induced brain injury through inhibition of neuronal oxidative stress and apoptosis.},
year = {2014},
url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091019},
}