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Oxidative Stress

The effect of melatonin on the liver of rats exposed to microwave radiation

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Djordjevic B, Sokolovic D, Kocic G, Veljkovic A, Despotovic M, Basic J, Jevtovic-Stoimenov T, Sokolovic DM. · 2015

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Melatonin reduced malondialdehyde in the liver of microwave-exposed rats but had no effect on the other analyzed parameters.

Plain English Summary

Summary written for general audiences

Researchers studied whether melatonin treatment (2 mg/kg) might favorably impact liver tissue in rats exposed to microwave radiation. The experiment used 84 six-weeks-old Wistar male rats exposed for 4 hours a day to microwaves at 900 MHz for 20, 40, and 60 days. Microwave exposure increased malondialdehyde after 40 days, protein carbonyl content after 20 days, and catalase and xanthine oxidase activity after 40 days. Melatonin reduced malondialdehyde after 40 days but had no effect on the other analyzed parameters.

Why This Matters

Rats were divided into four groups: a control group treated with saline, a group treated with melatonin only, a group exposed to microwaves only, and a group exposed to microwaves and also treated with melatonin. The researchers measured oxidative stress markers including malondialdehyde and carbonyl group content, as well as catalase, xanthine oxidase, and deoxyribonuclease I and II activity. Deoxyribonuclease I activity increased after 60 days of microwave exposure, while deoxyribonuclease II activity was unaffected. The researchers concluded that melatonin exerts certain antioxidant effects in the liver of rats exposed to microwaves, specifically by diminishing the intensity of lipid peroxidation.

Exposure Details

Magnetic Field
0.1 - 0.3 mT
Electric Field
54-160 V/m
Source/Device
900 MHz
Exposure Duration
4h a day, for 20, 40 and 60 days

Exposure Context

This study used 0.1 - 0.3 mT for magnetic fields:

This study used 54-160 V/m for electric fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.1 - 0.3 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

We aimed to clarify if melatonin treatment (2 mg/kg i.p.) may favorably impact the liver tissue in rats exposed to microwave radiation.

The experiment was performed on 84 six-weeks-old Wistar male rats exposed for 4h a day, for 20, 40 a...

Exposure to microwaves caused an increase in malondialdehyde after 40 (p < 0.01), protein carbonyl c...

Melatonin exerts certain antioxidant effects in the liver of rats exposed to microwaves, by diminishing the intensity of lipid peroxidation.

Cite This Study
Djordjevic B, Sokolovic D, Kocic G, Veljkovic A, Despotovic M, Basic J, Jevtovic-Stoimenov T, Sokolovic DM. (2015). The effect of melatonin on the liver of rats exposed to microwave radiation Bratisl Lek Listy. 116(2):96-100, 2015.
Show BibTeX
@article{b_2015_the_effect_of_melatonin_521,
  author = {Djordjevic B and Sokolovic D and Kocic G and Veljkovic A and Despotovic M and Basic J and Jevtovic-Stoimenov T and Sokolovic DM.},
  title = {The effect of melatonin on the liver of rats exposed to microwave radiation},
  year = {2015},
  
  url = {https://europepmc.org/article/med/25665474},
}
PubMed: 25665474

Cited By (14 papers)

Quick Questions About This Study

The study used 84 six-weeks-old Wistar male rats exposed for 4 hours a day to 900 MHz microwaves for 20, 40, and 60 days.
Microwave exposure caused increases in malondialdehyde, protein carbonyl content, catalase, and xanthine oxidase activity, and increased deoxyribonuclease I activity after 60 days.
Melatonin reduced malondialdehyde after 40 days but surprisingly had no effect on the other analyzed parameters.
Melatonin exerted certain antioxidant effects in the liver of rats exposed to microwaves by diminishing the intensity of lipid peroxidation.
Melatonin was administered at 2 mg/kg intraperitoneally.