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Cytoprotective response induced by electromagnetic stimulation on SH-SY5Y human neuroblastoma cell line.

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Osera C, Fassina L, Amadio M, Venturini L, Buoso E, Magenes G, Govoni S, Ricevuti G, Pascale A · 2011

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Electromagnetic stimulation at 2 mT and 75 Hz promoted a cytoprotective response in human neuroblastoma cells overexpressing amyloid precursor protein.

Plain English Summary

Summary written for general audiences

Researchers investigated the effects of an electromagnetic wave at 2 mT and 75 Hz on human neuroblastoma cells overexpressing amyloid precursor protein (APP). After prolonged electromagnetic treatment, lower mitochondrial activity and proliferation rate were observed, resulting in higher cellular quiescence. The treatment was also associated with an overall increase of HSP70 and superoxide dismutase-1 (SOD-1), and with increased expression of the enzyme ADAM10 and enhanced release of the neurotrophic factor sAPPα. The researchers suggested a possible use of this physical stimulation to improve the functional capability of cells to face noxae.

Why This Matters

The study used a neuronal cellular model characterized by overexpression of the amyloid precursor protein, which provided the experimental context for testing electromagnetic stimulation. Electromagnetic stimulation was found to promote the nonamyloidogenic processing of APP through ADAM10 and increased release of sAPPα, a product of ADAM10-mediated cleavage of APP. The authors noted that the cytoprotective response appeared contingent on the stimulus being properly administered in terms of dose and timing.

Exposure Details

Magnetic Field
2 mT
Source/Device
75 Hz

Exposure Context

This study used 2 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 2 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 10 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 75 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 75 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

In this study, under a tissue engineering viewpoint, we investigated the effects of an electromagnetic wave (magnetic field intensity, 2 mT; frequency, 75 Hz) on a neuronal cellular model characterized by the overexpression of the amyloid precursor protein (APP).

After a prolonged electromagnetic treatment, lower mitochondrial activity and proliferation rate, re...

In conclusion, these findings suggest that the electromagnetic stimulus, if properly administered in terms of dose and timing, is able to induce a cytoprotective response in the cell. Moreover, these results suggest a possible use of this particular physical stimulation to improve the functional capability of the cells to face noxae.

Cite This Study
Osera C, Fassina L, Amadio M, Venturini L, Buoso E, Magenes G, Govoni S, Ricevuti G, Pascale A (2011). Cytoprotective response induced by electromagnetic stimulation on SH-SY5Y human neuroblastoma cell line. Tissue Eng Part A. 17(19-20):2573-2582, 2011.
Show BibTeX
@article{c_2011_cytoprotective_response_induced_by_435,
  author = {Osera C and Fassina L and Amadio M and Venturini L and Buoso E and Magenes G and Govoni S and Ricevuti G and Pascale A},
  title = {Cytoprotective response induced by electromagnetic stimulation on SH-SY5Y human neuroblastoma cell line.},
  year = {2011},
  doi = {10.1089/ten.TEA.2011.0071},
  url = {https://www.liebertpub.com/doi/abs/10.1089/ten.TEA.2011.0071},
}
DOI: 10.1089/ten.TEA.2011.0071

Cited By (43 papers)

Quick Questions About This Study

The study used a neuronal cellular model characterized by the overexpression of the amyloid precursor protein (APP).
The electromagnetic wave had a magnetic field intensity of 2 mT and a frequency of 75 Hz.
After prolonged electromagnetic treatment, lower mitochondrial activity and proliferation rate were observed, resulting in higher cellular quiescence.
An overall increase of HSP70 and the free radical scavenger superoxide dismutase-1 enzyme (SOD-1) was detected.
The results suggest a possible use of this physical stimulation to improve the functional capability of cells to face noxae.