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Changes of dendritic spine density and morphology in the superficial layers of the medial entorhinal cortex induced by extremely low-frequency magnetic field exposure.

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Xiong J, He C, Li C, Tan G, Li J, Yu Z, Hu Z, Chen F. · 2013

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Magnetic field exposure at 0.5 mT physically damaged brain cell connections critical for memory formation in just 14 days.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to power line-frequency magnetic fields for 14-28 days and found significant damage to brain cell connections in the entorhinal cortex, a memory center. The exposure destroyed dendritic spines that enable brain cells to communicate, potentially explaining EMF-related cognitive problems.

Why This Matters

This study provides compelling evidence that even relatively low-level magnetic field exposure can alter the physical structure of brain cells in regions critical for learning and memory. The 0.5 mT exposure level used here is actually quite modest - comparable to what you might encounter near some household appliances or electrical installations, though higher than typical background levels in most homes. What makes this research particularly significant is that it demonstrates measurable biological changes at the cellular level, not just behavioral effects. The loss of dendritic spines represents actual structural damage to the brain's communication network. While this was an animal study, the medial entorhinal cortex serves the same memory-related functions in humans, and the spine changes observed mirror those seen in neurodegenerative diseases. The science demonstrates that EMF exposure can physically reshape the brain's architecture in ways that could impair cognitive function.

Exposure Details

Magnetic Field
0.5 mG
Source/Device
50 Hz ELM
Exposure Duration
14 and 28 days

Exposure Context

This study used 0.5 mG for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0.5 mGExtreme Concern5 mGFCC Limit2,000 mGEffects observed in the Slight Concern range (Building Biology)FCC limit is 4,000x higher than this exposure level

Study Details

To investigate the changes of Dendritic Spine Density and Morphology in the Superficial Layers of the Medial Entorhinal Cortex Induced by Extremely Low-Frequency Magnetic Field Exposure.

In the present study, we investigated the effects of chronic exposure (14 and 28 days) to a 0.5 mT 5...

The results showed that ELM exposure induced a decrease in the spine density in the dendrites of ste...

Cite This Study
Xiong J, He C, Li C, Tan G, Li J, Yu Z, Hu Z, Chen F. (2013). Changes of dendritic spine density and morphology in the superficial layers of the medial entorhinal cortex induced by extremely low-frequency magnetic field exposure. PLoS One. 2013 Dec 20; 8(12):e83561. doi: 10.1371/journal.pone.0083561.
Show BibTeX
@article{j_2013_changes_of_dendritic_spine_312,
  author = {Xiong J and He C and Li C and Tan G and Li J and Yu Z and Hu Z and Chen F. },
  title = {Changes of dendritic spine density and morphology in the superficial layers of the medial entorhinal cortex induced by extremely low-frequency magnetic field exposure.},
  year = {2013},
  
  url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083561},
}

Quick Questions About This Study

Researchers exposed rats to power line-frequency magnetic fields for 14-28 days and found significant damage to brain cell connections in the entorhinal cortex, a memory center. The exposure destroyed dendritic spines that enable brain cells to communicate, potentially explaining EMF-related cognitive problems.