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Impact of 60-GHz millimeter waves and corresponding heat effect on endoplasmic reticulum stress sensor gene expression.

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Le Quément C, Nicolaz CN, Habauzit D, Zhadobov M, Sauleau R, Le Dréan Y. · 2014

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MMW exposure at 20 mW/cm(2) inhibited TG-induced BIP and ORP150 overexpression, and this inhibition was linked to thermal effects.

Plain English Summary

Summary written for general audiences

Researchers exposed human skin cell lines to 60.4 GHz millimeter waves at incident power densities ranging from 1 to 20 mW/cm(2). The expression of ER stress sensors BIP and ORP150 was examined by real-time RT-PCR. MMW radiation did not change basal levels of BIP or ORP150 mRNA across any cell line, exposure duration, or power density. At 20 mW/cm(2), MMW exposure inhibited thapsigargin-induced overexpression of BIP and ORP150. This inhibition was attributed to thermal effects from the MMW exposure.

Why This Matters

The study aimed to investigate potential effects of millimeter wave radiation on cellular endoplasmic reticulum stress. Researchers assessed co-exposure with the ER stress inducer thapsigargin. The highest incident power density tested corresponded to the ICNIRP local exposure limit for the general public.

Exposure Details

Power Density
1 to 20 mW/cm²
Source/Device
60.4 GHz

Exposure Context

This study used 1 to 20 mW/cm² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1 to 20 mW/cm²Extreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²Effects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 60.40 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 60.40 GHzPower lines50/60 HzCell phones~1 GHzWiFi2.4 GHzLogarithmic scale

Study Details

The aim of this study was to investigate potential effects of MMW radiation on the cellular endoplasmic reticulum (ER) stress.

Human skin cell lines were exposed at 60.4 GHz, with incident power densities (IPD) ranging between ...

Our experimental data demonstrated that MMW radiations do not change BIP or ORP150 mRNA basal levels...

Experimental controls showed that this inhibition is linked to the thermal effect resulting from the MMW exposure.

Cite This Study
Le Quément C, Nicolaz CN, Habauzit D, Zhadobov M, Sauleau R, Le Dréan Y. (2014). Impact of 60-GHz millimeter waves and corresponding heat effect on endoplasmic reticulum stress sensor gene expression. Bioelectromagnetics. 35(6):444-451, 2014.
Show BibTeX
@article{c_2014_impact_of_60ghz_millimeter_1142,
  author = {Le Quément C and Nicolaz CN and Habauzit D and Zhadobov M and Sauleau R and Le Dréan Y.},
  title = {Impact of 60-GHz millimeter waves and corresponding heat effect on endoplasmic reticulum stress sensor gene expression.},
  year = {2014},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/25099539/},
}
PubMed: 25099539

Cited By (24 papers)

Quick Questions About This Study

The study aimed to investigate potential effects of millimeter wave radiation on cellular endoplasmic reticulum stress.
Human skin cell lines were exposed to 60.4 GHz millimeter waves at incident power densities ranging from 1 to 20 mW/cm(2).
No, millimeter wave radiation did not change basal levels of BIP or ORP150 mRNA regardless of cell line, exposure duration, or power density.
At 20 mW/cm(2), millimeter wave exposure inhibited thapsigargin-induced overexpression of BIP and ORP150.
No, experimental controls showed the inhibition was linked to thermal effects from the millimeter wave exposure.