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Modulation of hydrogen peroxide production in cellular systems by low level magnetic fields.

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Martino CF, Castello PR · 2011

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Reducing the Earth's magnetic field suppressed hydrogen peroxide production in cancer cells and endothelial cells.

Plain English Summary

Summary written for general audiences

Researchers studied how suppressing the Earth's magnetic field to between 0.2 µT and 2 µT affected hydrogen peroxide production in several cell types. The cell types tested were a human fibrosarcoma cancer cell line, a pancreatic cancer cell line, and bovine pulmonary artery endothelial cells. Reducing the Earth's magnetic field suppressed hydrogen peroxide production in the cancer cells and the endothelial cells. Adding catalase and a superoxide dismutase mimetic called MnTBAP inhibited the magnetic field effect.

Why This Matters

The control condition used cells exposed to the geomagnetic field, which ranged from 45 µT to 60 µT. The low-level magnetic field condition ranged from 0.2 µT to 2 µT, representing a suppression of the Earth's normal field. The addition of catalase and superoxide dismutase mimetic MnTBAP inhibited the magnetic field effect. The researchers suggested that modulating reactive oxygen species production by magnetic fields may open new venues of biomedical research and therapeutic strategies.

Exposure Details

Magnetic Field
0.0002 -0.002 mT

Exposure Context

This study used 0.0002 -0.002 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.0002 -0.002 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Severe Concern range (Building Biology)FCC limit is 1,000 times higher than this level

Study Details

In this manuscript, we present data on the influence of the suppression of the Earth's magnetic field (low level magnetic fields or LLF) which magnitudes range from 0.2 µT to 2 µT on the modulation of hydrogen peroxide (H(2)O(2)) in human fibrosarcoma cancer cell line HT1080, pancreatic AsPC-1 cancer cell line, and bovine pulmonary artery endothelial cells (PAEC) exposed to geomagnetic field (control; 45 µT-60 µT).

Reduction of the Earth's magnetic field suppressed H(2)O(2) production in cancer cells and PAEC. The...

Cite This Study
Martino CF, Castello PR (2011). Modulation of hydrogen peroxide production in cellular systems by low level magnetic fields. PLoS One. 6(8):e22753, 2011.
Show BibTeX
@article{cf_2011_modulation_of_hydrogen_peroxide_423,
  author = {Martino CF and Castello PR},
  title = {Modulation of hydrogen peroxide production in cellular systems by low level magnetic fields.},
  year = {2011},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/21887222/},
}
PubMed: 21887222

Cited By (76 papers)

View all 76 citing papers on Semantic Scholar

Quick Questions About This Study

The low-level magnetic field condition ranged from 0.2 µT to 2 µT, while the control condition was the geomagnetic field at 45 µT to 60 µT.
The study tested a human fibrosarcoma cancer cell line, a pancreatic cancer cell line, and bovine pulmonary artery endothelial cells.
Reduction of the Earth's magnetic field suppressed hydrogen peroxide production in cancer cells and endothelial cells.
The addition of catalase and the superoxide dismutase mimetic MnTBAP inhibited the magnetic field effect.
The researchers suggested that modulating reactive oxygen species production by magnetic fields may open new venues of biomedical research and therapeutic strategies.