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DNA & Genetic Damage

Effects of gamma rays, ultraviolet radiation, sunlight, microwaves and electromagnetic fields on gene expression mediated by human immunodeficiency virus promoter.

No Effects Found

Libertin CR, Panozzo J, Groh KR, Chang-Liu CM, Schreck S, Woloschak GE. · 1994

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Electromagnetic fields showed no effect on HIV gene activation in cells, while microwaves only caused effects through heat generation.

Plain English Summary

Summary written for general audiences

Researchers tested whether different types of radiation and electromagnetic fields could activate HIV gene expression in laboratory cells. They found that only ultraviolet light and microwaves (when they generated excessive heat) could trigger HIV activation, while electromagnetic fields and microwaves at normal temperatures had no effect. This suggests that not all forms of radiation affect viral gene activity in the same way.

Study Details

The aim of this study is to investigate Effects of gamma rays, ultraviolet radiation, sunlight, microwaves and electromagnetic fields on gene expression mediated by human immunodeficiency virus promoter.

Using HeLa cells stably transfected with a construct containing the chloramphenicol acetyl transfera...

These results demonstrated ultraviolet-light-induced transcription from the HIV promoter, as has bee...

These results demonstrate that not all types of radiation and not all DNA-damaging agents are capable of inducing HIV. We hypothesize that induction of HIV transcription may be mediated by several different signals after exposure to radiation.

Cite This Study
Libertin CR, Panozzo J, Groh KR, Chang-Liu CM, Schreck S, Woloschak GE. (1994). Effects of gamma rays, ultraviolet radiation, sunlight, microwaves and electromagnetic fields on gene expression mediated by human immunodeficiency virus promoter. Radiat Res. 140(1):91-96, 1994.
Show BibTeX
@article{cr_1994_effects_of_gamma_rays_3197,
  author = {Libertin CR and Panozzo J and Groh KR and Chang-Liu CM and Schreck S and Woloschak GE.},
  title = {Effects of gamma rays, ultraviolet radiation, sunlight, microwaves and electromagnetic fields on gene expression mediated by human immunodeficiency virus promoter.},
  year = {1994},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/7938460/},
}
PubMed: 7938460

Cited By (20 papers)

Quick Questions About This Study

No, electromagnetic field exposure had no effect on HIV activation in laboratory cells. A 1994 study found that EMFs could not trigger HIV gene expression, unlike ultraviolet light which did activate the virus. This suggests EMFs don't stimulate dormant HIV.
Microwaves alone don't damage DNA or activate viral genes in cells. However, when microwaves generate excessive heat in laboratory conditions, they can trigger biological responses. Normal microwave exposure without overheating showed no cellular effects in this research.
This study found no evidence that electromagnetic fields affect immune-related gene activity. EMF exposure didn't activate HIV genes in laboratory cells, suggesting EMFs may not significantly impact certain immune system functions at the cellular level.
Only ultraviolet light consistently activated HIV genes in this laboratory study. Gamma rays, sunlight, electromagnetic fields, and normal microwave exposure had no effect. This suggests different radiation types have very different biological impacts on viral activity.
Electromagnetic fields showed no effect on HIV gene expression in laboratory cells. While some forms of radiation like UV light can alter gene activity, EMFs did not trigger changes in viral gene transcription in this controlled study.