Calcium-binding proteins and GFAP immunoreactivity alterations in murine hippocampus after 1 month of exposure to 835 MHz radiofrequency at SAR values of 1.6 and 4.0 W/kg
Maskey D, Kim HJ, Kim HG, Kim MJ. · 2012
View Original AbstractMice exposed to 835 MHz radiofrequency at 1.6 and 4.0 W/kg for one month showed decreased calcium-binding proteins and increased GFAP in the hippocampus.
Plain English Summary
Researchers exposed mice to 835 MHz radiofrequency at SAR values of 1.6 W/kg and 4.0 W/kg for one month to study effects in the hippocampus. Compared with a sham control group, both exposed groups showed decreased calbindin D28-k and calretinin, loss of immunoreactive cells, and increased GFAP with hypertrophic cytoplasmic processes. The group exposed at 4.0 W/kg showed a more prominent decrease in calbindin and calretinin, and more prominent GFAP immunoreactivity, than the group exposed at 1.6 W/kg.
Why This Matters
The study compared two exposure levels against a sham control group to see whether SAR value influenced the size of the effect. The researchers noted that the higher SAR group showed a more prominent decrement in calcium-binding proteins alongside neuronal loss. According to the researchers, decrement in the calcium-binding proteins can affect the calcium-buffering capacity leading to cell death. The researchers also noted that increased GFAP immunoreactivity and changes in astrocyte morphology may mediate brain injury due to radiofrequency exposure.
Exposure Details
- SAR
- 1.6 and 4.0 W/kg
- Source/Device
- 835MHz
- Exposure Duration
- 1 month
Exposure Context
This study used 1.6 and 4.0 W/kg for SAR (device absorption):
- 4x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
To examine calcium-binding proteins and GFAP immunoreactivity alterations in murine hippocampus after 1 month of exposure to 835 MHz radiofrequency at SAR values of 1.6 and 4.0 W/kg
Different SAR values [1.6 (E1.6 group) and 4.0 (E4 group) W/kg] were applied to determine the distr...
E4 group showed a prominent decrement in CB and CR IR than the E1.6 group due to down-regulation of ...
Show BibTeX
@article{d_2012_calciumbinding_proteins_and_gfap_139,
author = {Maskey D and Kim HJ and Kim HG and Kim MJ.},
title = {Calcium-binding proteins and GFAP immunoreactivity alterations in murine hippocampus after 1 month of exposure to 835 MHz radiofrequency at SAR values of 1.6 and 4.0 W/kg},
year = {2012},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0304394011015473},
}