Chronic 835-MHz radiofrequency exposure to mice hippocampus alters the distribution of calbindin and GFAP immunoreactivity.
Maskey D, Pradhan J, Aryal B, Lee CM, Choi IY, Park KS, Kim SB, Kim HG, Kim MJ · 2010
View Original AbstractChronic 835-MHz radiofrequency exposure was associated with signs of hippocampus damage in rats, including cell loss and increased markers of astrocyte activity.
Plain English Summary
Researchers investigated the effect of 835-MHz radiofrequency exposure on rat hippocampus for 3 months using immunohistochemical methods. A decrease in calbindin immunoreactivity was observed in the exposed group, with loss of interneurons and pyramidal cells in the CA1 area and loss of granule cells. An overall increase in GFAP immunoreactivity was observed in the hippocampus of exposed rats, and apoptotic cells were detected in the CA1, CA3 areas and dentate gyrus.
Why This Matters
The study tracked changes in the hippocampus using calbindin (CB) and glial fibrillary acidic protein (GFAP) antibodies by immunohistochemical method. The researchers suggested that the increase in GFAP immunoreactivity could be consistent with reactive astrocytosis, described as an abnormal increase in the number of astrocytes due to the loss of nearby neurons. The researchers suggested that the decrease in calbindin immunoreactivity accompanying apoptosis, together with the increase in GFAP immunoreactivity, might be morphological parameters of hippocampus damage.
Exposure Details
- SAR
- 1.6 W/kg
- Electric Field
- 59.56 V/m
- Source/Device
- 835 MHz
- Exposure Duration
- continuous for 8 hr/day for 3 months
Exposure Context
This study used 59.56 V/m for electric fields:
- 198.5x above the Building Biology guideline of 0.3 V/m
This study used 1.6 W/kg for SAR (device absorption):
- 4x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In the present study, we investigated the effect of RF exposure on rat hippocampus at 835 MHz with low energy (specific absorption rate: SAR = 1.6 W/kg) for 3 months by using both CB and glial fibrillary acidic protein (GFAP) specific antibodies by immunohistochemical method.
Decrease in CB immunoreactivity (IR) was noted in exposed (E1.6) group with loss of interneurons and...
Show BibTeX
@article{d_2010_chronic_835mhz_radiofrequency_exposure_138,
author = {Maskey D and Pradhan J and Aryal B and Lee CM and Choi IY and Park KS and Kim SB and Kim HG and Kim MJ},
title = {Chronic 835-MHz radiofrequency exposure to mice hippocampus alters the distribution of calbindin and GFAP immunoreactivity.},
year = {2010},
url = {https://www.sciencedirect.com/science/article/abs/pii/S000689931001190X},
}