6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
Shield Your Body
Brain & Nervous System

Effects of pre- and postnatal exposure to extremely low-frequency electric fields on mismatch negativity component of the auditory event-related potentials: Relation to oxidative stress.

Bioeffects Seen

Akpınar D, Gok DK, Hidisoglu E, Aslan M, Ozen S, Agar A, Yargicoglu P · 2016

View Original Abstract
Share:

Rats exposed to an extremely low-frequency electric field before and/or after birth showed decreased MMN amplitudes and changes in oxidative stress markers in the brain.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to an electric field at 12 kV/m for 1 hour per day, dividing them into control, prenatal, postnatal, and prenatal-plus-postnatal groups. The mismatch negativity amplitude was decreased in all exposed groups compared with the control group. Levels of 4-HNE, a marker of lipid peroxidation, were significantly increased in the postnatal group compared with the control group, while protein carbonyl levels were significantly decreased in the prenatal-plus-postnatal group compared with the control, prenatal, and postnatal groups.

Why This Matters

After exposure, MMN was recorded by electrodes positioned stereotaxically to the surface of the dura, and brain tissues were then removed for histological and biochemical analyses. The MMN amplitude was higher to deviant tones than to standard tones in the normal pattern, but this amplitude was reduced across all exposed groups. The researchers suggested that the EF-related decreases in MMN amplitudes were possibly induced by lipid peroxidation.

Exposure Details

Electric Field
12000 V/m
Source/Device
50 Hz
Exposure Duration
1 h/day

Exposure Context

This study used 12000 V/m for electric fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

our present study aimed to investigate MMN and oxidative brain damage in rats exposed to EF (12 kV/m, 1 h/day).

Rats were divided into four groups, namely control (C), prenatal (Pr), postnatal (Po), and prenatal+...

The MMN amplitude was higher to deviant tones than to standard tones. It was decreased in all experi...

Cite This Study
Akpınar D, Gok DK, Hidisoglu E, Aslan M, Ozen S, Agar A, Yargicoglu P (2016). Effects of pre- and postnatal exposure to extremely low-frequency electric fields on mismatch negativity component of the auditory event-related potentials: Relation to oxidative stress. Electromagn Biol Med. 35(3):245-259, 2016.
Show BibTeX
@article{d_2016_effects_of_pre_and_318,
  author = {Akpınar D and Gok DK and Hidisoglu E and Aslan M and Ozen S and Agar A and Yargicoglu P},
  title = {Effects of pre- and postnatal exposure to extremely low-frequency electric fields on mismatch negativity component of the auditory event-related potentials: Relation to oxidative stress.},
  year = {2016},
  doi = {10.3109/15368378.2015.1076727},
  url = {https://www.tandfonline.com/doi/abs/10.3109/15368378.2015.1076727},
}
DOI: 10.3109/15368378.2015.1076727

Cited By (4 papers)

Quick Questions About This Study

Rats were exposed to an electric field at 12 kV/m for 1 hour per day.
Rats were divided into four groups: control, prenatal, postnatal, and prenatal-plus-postnatal, with pregnant rats in the prenatal and prenatal-plus-postnatal groups exposed during pregnancy, and postnatal and prenatal-plus-postnatal rats exposed for three months after birth.
MMN amplitude was decreased in all experimental groups compared with the control group.
4-HNE levels were significantly increased in the postnatal group with respect to the control group.
The researchers suggested that the electric-field-related decreases in MMN amplitudes were possibly induced by lipid peroxidation.