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Effects of low intensity static magnetic field on FTIR spectra and ROS production in SH-SY5Y neuronal-like cells.

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Calabrò E, Condello S, Currò M, Ferlazzo N, Caccamo D, Magazù S, Ientile R · 2013

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Exposure of human neuronal-like cells to a 2.2 mT static magnetic field altered protein structures and was associated with increased reactive oxygen species production.

Plain English Summary

Summary written for general audiences

Researchers investigated the effects of exposing human SH-SY5Y neuronal-like cells to a uniform static magnetic field at an intensity of 2.2 mT. Fourier transform infrared spectroscopy analysis showed that exposure changed the secondary structure of cellular proteins and lipid components. A decrease of membrane mitochondrial potential up to 30% was measured after 24 h of exposure, and this effect was associated with reactive oxygen species production increase.

Why This Matters

The 2.2 mT intensity used in this study is less than the recommended public exposure limits set by the International Commission on Non-Ionizing Radiation Protection. After 4 hours of exposure, the vibration bands relative to the methylene group increased significantly. Further exposure up to 24 hours produced evident shifts of amide I and II modes and a relative increase in beta-sheet contents with respect to alpha-helix components. The researchers concluded that a moderate static magnetic field causes alteration in cell homeostasis, as indicated by the observed changes in protein structures.

Exposure Details

Magnetic Field
2.2 mT
Exposure Duration
24h

Exposure Context

This study used 2.2 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 2.2 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 11 times the FCC limit

Study Details

We investigated the effects produced by the exposure of human SH-SY5Y neuronal-like cells to a uniform magnetic field at intensities of 2.2 mT, which is less than the recommended public exposure limits set by the International Commission on Non-Ionizing Radiation Protection (ICNIRP).

A decrease of membrane mitochondrial potential up to 30% was measured after 24 h of exposure to SMF ...

Fourier transform infrared spectroscopy (FTIR) analysis showed that exposure to a static magnetic in...

Our study demonstrated that a moderate SMF causes alteration in cell homeostasis, as indicated by FTIR spectroscopy observations of changes in protein structures that are part of cell response to magnetic field exposure.

Cite This Study
Calabrò E, Condello S, Currò M, Ferlazzo N, Caccamo D, Magazù S, Ientile R (2013). Effects of low intensity static magnetic field on FTIR spectra and ROS production in SH-SY5Y neuronal-like cells. Bioelectromagnetics. 34(8):618-629, 2013.
Show BibTeX
@article{e_2013_effects_of_low_intensity_326,
  author = {Calabrò E and Condello S and Currò M and Ferlazzo N and Caccamo D and Magazù S and Ientile R},
  title = {Effects of low intensity static magnetic field on FTIR spectra and ROS production in SH-SY5Y neuronal-like cells.},
  year = {2013},
  doi = {10.1002/bem.21815},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.21815},
}
DOI: 10.1002/bem.21815

Cited By (70 papers)

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Quick Questions About This Study

The study used human SH-SY5Y neuronal-like cells.
Cells were exposed to a uniform static magnetic field at an intensity of 2.2 mT, which is below recommended public exposure limits.
A decrease of membrane mitochondrial potential up to 30% was measured after 24 h of exposure, and this effect was associated with reactive oxygen species production increase.
FTIR analysis showed that exposure changed the secondary structure of cellular proteins and lipid components, with shifts in amide modes and a relative increase in beta-sheet contents after 24 hours.
The researchers concluded that a moderate static magnetic field causes alteration in cell homeostasis, as indicated by FTIR spectroscopy observations of changes in protein structures.