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Brain & Nervous System

Egr1 mediated the neuronal differentiation induced by extremely low-frequency electromagnetic fields

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Authors not listed · 2014

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The study found that Egr1 is one of the key transcription factors in ELF-EMF-induced neuronal differentiation and that transplantations of ELF-EMF-induced neurons significantly alleviate symptoms in mouse models of neurodegenerative disease.

Plain English Summary

Summary written for general audiences

Human bone marrow-mesenchymal stem cells were exposed to ELF-EMF at 50 Hz and 1 mT for 8 days. The hBM-MSC derived neurons were then analyzed by immunofluorescence and quantitative RT-PCR. Researchers analyzed the transcriptome of neuronal cells after an 8-day ELF-EMF exposure (50 Hz, 1 mT) and compared the transcriptional profiles to control cells. Early growth response protein 1 (Egr1) is one of the key transcription factors in ELF-EMF-induced neuronal differentiation. Transplantations of ELF-EMF-induced neurons significantly alleviate symptoms in mouse models of neurodegenerative disease.

Why This Matters

The aim of this study is to understand the underlying mechanisms that mediate ELF-EMF-induced neuronal differentiation and also to harness these mechanisms for cell transplantation assays. Although several mechanisms are known to regulate ELF-EMF-induced neuronal differentiation, a key factor that mediates neurogenic potentials by the ELF-EMF is largely unknown. These findings indicate that a specific transcriptional factor, Egr1, mediates ELF-EMF-induced neuronal differentiations, and demonstrate the promise of ELF-EMF based cell replacement therapies for neurodegenerative diseases.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study.

Cite This Study
Unknown (2014). Egr1 mediated the neuronal differentiation induced by extremely low-frequency electromagnetic fields.
Show BibTeX
@article{egr1_mediated_the_neuronal_differentiation_induced_by_extremely_low_frequency_electromagnetic_fields_ce2075,
  author = {Unknown},
  title = {Egr1 mediated the neuronal differentiation induced by extremely low-frequency electromagnetic fields},
  year = {2014},
  doi = {10.1016/j.lfs.2014.02.022},
  
}
DOI: 10.1016/j.lfs.2014.02.022PubMed: 24603130

Quick Questions About This Study

Human bone marrow-mesenchymal stem cells (hBM-MSCs) were exposed to ELF-EMF (50 Hz frequency, 1mT intensity) for 8 days.
Early growth response protein 1 (Egr1) is one of the key transcription factors in ELF-EMF-induced neuronal differentiation.
Transplantations of ELF-EMF-induced neurons significantly alleviate symptoms in mouse models of neurodegenerative disease.
The aim of this study is to understand the underlying mechanisms that mediate ELF-EMF-induced neuronal differentiation and also to harness these mechanisms for cell transplantation assays.
These findings indicate that a specific transcriptional factor, Egr1, mediates ELF-EMF-induced neuronal differentiations, and demonstrate the promise of ELF-EMF based cell replacement therapies for neurodegenerative diseases.