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Electroanesthesia and some thalamic evoked responses

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Eustace F. G. Douglas, Sanford J. Larson, Anthony Sances, Jr. · 1967

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Electroanesthesia reduced and then eliminated thalamic evoked potentials in monkeys at currents sufficient for surgical anesthesia.

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Researchers implanted chronic bipolar electrodes in the centre median and ventralis anterior thalamic nuclei of squirrel and stump-tail Macaque monkeys. They applied rectangular current pulses of 70 Hz and 3 ms duration between the inion and nasion to induce electroanesthesia. As current intensity increased, the amplitude of depth evoked potentials decreased gradually and disappeared at anesthesia levels sufficient for surgery. Peripheral sensory responses were similarly depressed, and cross-thalamic responses vanished when surface responses disappeared.

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Eustace F. G. Douglas, Sanford J. Larson, Anthony Sances, Jr. (1967). Electroanesthesia and some thalamic evoked responses.
Show BibTeX
@article{electroanesthesia_and_some_thalamic_evoked_responses_g5751,
  author = {Eustace F. G. Douglas and Sanford J. Larson and Anthony Sances and Jr.},
  title = {Electroanesthesia and some thalamic evoked responses},
  year = {1967},
  
  
}
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Quick Questions About This Study

Squirrel and stump-tail Macaque monkeys received chronic bipolar electrodes in the centre median and ventralis anterior thalamic nuclei.
Rectangular current pulses of 70 Hz and 3 ms duration biased above zero were applied between the inion and nasion.
Increasing current intensity gradually reduced the amplitude of depth evoked potentials until they disappeared at surgical anesthesia levels.
The absence of response in VA with CM stimulation and vice-versa occurred at the same time as the surface recorded response disappeared.