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Stimulation of production of tumor necrosis factor by murine macrophages when exposed in vio and in vitro to weak electromagnetic waves in the centimeter range

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Novoselova ET, Fesenko EE. · 1998

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Microwave radiation 1,000 times weaker than cell phones significantly altered immune system function in this study.

Plain English Summary

Summary written for general audiences

Russian researchers exposed mice to extremely weak microwave radiation (8.15-18 GHz) at power levels 1,000 times lower than cell phones. The exposure significantly increased production of tumor necrosis factor, a key immune protein, suggesting even very low-level microwaves can alter immune function.

Why This Matters

This 1998 study reveals something remarkable: microwave radiation at power densities of just 1 microW/cm2 can measurably alter immune function. To put this in perspective, this exposure level is roughly 1,000 times weaker than what your cell phone produces during a call, yet it still triggered significant biological responses in immune cells. The researchers found increased tumor necrosis factor production, which plays a crucial role in inflammation and immune responses throughout the body. What makes this particularly significant is that the effect occurred both in living animals and in isolated cells, suggesting a direct biological mechanism rather than a secondary stress response. The reality is that our immune systems appear far more sensitive to electromagnetic fields than regulatory agencies acknowledge, responding to exposures well below current safety limits.

Exposure Details

Power Density
0.001 µW/m²
Source/Device
8.15-18 GHz

Exposure Context

This study used 0.001 µW/m² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.001 µW/m²Extreme Concern - 1,000 uW/m2FCC Limit - 10M uW/m2Effects observed in the No Concern rangeFCC limit is 10,000,000,000x higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 18 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 18 GHzPower lines50/60 HzCell phones~1 GHzWiFi2.4 GHzLogarithmic scale

Study Details

To investigate stimulation of production of tumor necrosis factor by murine macrophages when exposed in vio and in vitro to weak electromagnetic waves in the centimeter range

Whole-body microwave sinusoidal irradiation of male NMRI mice, exposure of macrophages in vitro, and...

The role of microwaves as a factor interfering with the process of cell immunity is discussed.

Cite This Study
Novoselova ET, Fesenko EE. (1998). Stimulation of production of tumor necrosis factor by murine macrophages when exposed in vio and in vitro to weak electromagnetic waves in the centimeter range Biofizika 43(6):1132-1333, 1998.
Show BibTeX
@article{et_1998_stimulation_of_production_of_1233,
  author = {Novoselova ET and Fesenko EE.},
  title = {Stimulation of production of tumor necrosis factor by murine macrophages when exposed in vio and in vitro to weak electromagnetic waves in the centimeter range},
  year = {1998},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/10079935/},
}

Cited By (11 papers)

Quick Questions About This Study

Yes, Russian research found that extremely weak microwaves at 8.15-18 GHz significantly increased tumor necrosis factor production in mouse immune cells. The power levels were 1,000 times lower than cell phones, suggesting even minimal microwave exposure can alter immune responses.
Tumor necrosis factor is a key immune protein that helps fight infections and cancer. When mice were exposed to 8.15-18 GHz microwaves at 1 microW/cm2, their macrophages produced significantly more of this protein, indicating enhanced immune activation from weak radiation.
The microwave radiation was extremely weak at just 1 microW/cm2 power density - about 1,000 times weaker than typical cell phone emissions. Despite this ultra-low intensity, the 8.15-18 GHz frequency range still triggered measurable changes in immune cell function.
Yes, macrophages (immune cells that fight infections) significantly increased tumor necrosis factor production when exposed to 8.15-18 GHz microwaves at power levels far below cell phones. This occurred both in living mice and isolated cell cultures.
The 1998 study by Novoselova and Fesenko demonstrated that extremely weak 8.15-18 GHz microwaves can enhance immune protein production in mice. This suggests microwaves may interfere with normal immune processes even at very low power levels.