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Microwaves and cellular immunity. I. Effect of whole body microwave irradiation on tumor necrosis factor production in mouse cells.

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Fesenko, EE, Makar, VR, Novoselova, EG, Sadovnikov, VB, · 1999

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Microwave radiation at 1 microW/cm2 altered mouse immune function more effectively than powerful immune stimulants, with effects lasting days after exposure.

Plain English Summary

Summary written for general audiences

Russian researchers exposed mice to low-level microwave radiation and found it significantly altered immune system function. Short exposures boosted immune cell activity, while longer exposure suppressed it. These effects persisted for days after radiation ended, showing even weak microwaves can disrupt normal immunity.

Why This Matters

This study reveals something remarkable: microwave radiation at just 1 microW/cm2 - a power level thousands of times lower than current safety limits - triggered measurable changes in immune system function. The researchers found that microwaves were actually more effective at stimulating TNF production than lipopolysaccharide, one of the most potent known immune stimulants. What makes this particularly significant is the biphasic response pattern: short-term exposure boosted immunity while chronic exposure suppressed it. This suggests our immune systems may initially mobilize against EMF as a stressor, then become depleted with prolonged exposure. The persistence of effects for three days after exposure ended indicates these aren't just temporary disruptions, but potentially lasting biological changes. While some might argue enhanced immunity sounds beneficial, disrupting the delicate balance of immune function can lead to autoimmune conditions or chronic inflammation.

Exposure Details

Power Density
0.001 µW/m²
Source/Device
8.15-18 GHz (1 Hz within)
Exposure Duration
5 h to 3 days.

Exposure Context

This study used 0.001 µW/m² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0.001 µW/m²Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the No Concern range (Building Biology)FCC limit is 10,000,000,000x higher than this exposure level

Study Details

The aim of this study is to investigate Microwaves and cellular immunity. I. Effect of whole body microwave irradiation on tumor necrosis factor production in mouse cells.

Whole body microwave sinusoidal irradiation of male NMRI mice with 8.15-18 GHz (1 Hz within) at a po...

Cite This Study
Fesenko, EE, Makar, VR, Novoselova, EG, Sadovnikov, VB, (1999). Microwaves and cellular immunity. I. Effect of whole body microwave irradiation on tumor necrosis factor production in mouse cells. Bioelectrochem Bioenerg 49(1):29-35, 1999.
Show BibTeX
@article{fesenko_1999_microwaves_and_cellular_immunity_969,
  author = {Fesenko and EE and Makar and VR and Novoselova and EG and Sadovnikov and VB and},
  title = {Microwaves and cellular immunity. I. Effect of whole body microwave irradiation on tumor necrosis factor production in mouse cells.},
  year = {1999},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/10619445/},
}

Quick Questions About This Study

Russian researchers exposed mice to low-level microwave radiation and found it significantly altered immune system function. Short exposures boosted immune cell activity, while longer exposure suppressed it. These effects persisted for days after radiation ended, showing even weak microwaves can disrupt normal immunity.