Radiofrequency fields, transthyretin, and Alzheimer's disease
Söderqvist F, Hardell L, Carlberg M, Mild KH · 2010
View Original AbstractA study of 313 subjects found a statistically significant association between longer time since first use of mobile and cordless phones and higher serum transthyretin levels.
Plain English Summary
Researchers proposed that transthyretin (TTR), a protein that sequesters amyloid-beta, might help explain findings related to radiofrequency exposure and Alzheimer's disease. In a provocation study on 41 persons exposed for 30 minutes to an 890-MHz GSM signal at 1.0 Watt/kg to the temporal area of the brain, serum TTR was found to be statistically significantly increased 60 minutes after exposure. In a cross-sectional study on 313 subjects, a statistically significantly positive association was found between serum TTR and time since first use of mobile phones and desktop cordless phones combined (P=0.03).
Why This Matters
Studies have shown that patients with Alzheimer's disease have lowered TTR concentrations in the cerebrospinal fluid, and researchers have attributed the onset of Alzheimer's disease to insufficient sequestering of amyloid-beta by TTR. The researchers used serum TTR as a marker of cerebrospinal fluid TTR in their cross-sectional study. In the cross-sectional study, use of oral snuff also yielded statistically significantly increased serum TTR concentrations. Nicotine has been associated with decreased risk for Alzheimer's disease and with upregulation of the TTR gene in choroid plexus but not in the liver, another source of serum TTR. The researchers proposed that TTR might be involved in the findings of radiofrequency exposure benefit in Alzheimer's disease mice.
Exposure Details
- SAR
- 1 W/kg
- Source/Device
- 890-MHz GSM
- Exposure Duration
- 30 min
Exposure Context
This study used 1 W/kg for SAR (device absorption):
- 2.5x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
Based on our studies on humans on RF from wireless phones, we propose that transthyretin (TTR) might explain the findings.
In a cross-sectional study on 313 subjects, we used serum TTR as a marker of cerebrospinal fluid TT...
In a provocation study on 41 persons exposed for 30 min to an 890-MHz GSM signal with specific absor...
We propose that TTR might be involved in the findings of RF exposure benefit in AD mice.
Show BibTeX
@article{f_2010_radiofrequency_fields_transthyretin_and_122,
author = {Söderqvist F and Hardell L and Carlberg M and Mild KH},
title = {Radiofrequency fields, transthyretin, and Alzheimer's disease},
year = {2010},
url = {https://content.iospress.com/articles/journal-of-alzheimers-disease/jad01395},
}