Effect of ELF-EMF on cognitive functions, analgesia, and oxidative stress in rats with PTZ-induced epilepsy
Gülmez K, Demirkazık A, Taşkıran AŞ · 2025
A statistically significant difference was observed in learning and short-term memory between the EMF+PTZ group and the PTZ group.
Plain English Summary
Twenty-four Wistar albino male rats were divided into sham, EMF, PTZ, and EMF+PTZ groups and exposed to alternating 50-Hz and 5-mT EMF for 165 min a day for 7 days while epileptic seizures were induced with PTZ. A statistically significant difference was observed in learning and short-term memory between the EMF+PTZ group and the PTZ group. Analgesia latency statistically significantly increased in the ELF-EMF and ELF-EMF+PTZ groups compared with both the control and epilepsy groups. TOS increased in the prefrontal cortex of the PTZ group versus sham, increased in the hippocampus of both PTZ and ELF-EMF+PTZ groups versus sham, and ELF-EMF decreased the hippocampal TOS increase in the PTZ group.
Why This Matters
The study aimed to examine ELF-EMF effects on cognitive functions and analgesia via total oxidant status (TOS) and total antioxidant status (TAS) in a PTZ-induced epilepsy model. Oxidative stress marker levels were measured. Statistical analysis employed univariate multifactorial one-way ANOVA with post hoc Tukey's test for pairwise comparisons.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{glmez_k_demirkazk_a_takran_a_ce3934,
author = {Gülmez K and Demirkazık A and Taşkıran AŞ},
title = {Effect of ELF-EMF on cognitive functions, analgesia, and oxidative stress in rats with PTZ-induced epilepsy},
year = {2025},
doi = {10.1080/15368378.2025.2593267},
}