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Electromagnetic Field Treatment Protects Against and Reverses Cognitive Impairment in Alzheimer's Disease Mice

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Arendash GW, Sanchez-Ramos J, Mori T, Mamcarz M, Lin X, Runfeldt M, Wang L, Zhang G, Sava V, Tan J, Cao C · 2010

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Long-term EMF exposure at 918 MHz was found to provide cognitive benefits and reduce brain amyloid-beta deposition in Alzheimer's disease mice.

Plain English Summary

Summary written for general audiences

Researchers studied the effects of long-term EMF exposure at 918 MHz and 0.25 w/kg on both normal mice and transgenic mice bred to develop Alzheimer's-like cognitive impairment. Both cognitive-protective and cognitive-enhancing effects of EMF exposure were discovered for both normal mice and transgenic mice destined to develop Alzheimer's-like cognitive impairment. In Alzheimer's disease mice, long-term EMF exposure reduced brain amyloid-beta deposition through anti-aggregation actions and increased brain temperature during exposure periods. The researchers concluded that EMF exposure may represent a non-invasive, non-pharmacologic therapeutic against Alzheimer's disease, while cautioning against directly extrapolating these mouse findings to humans.

Why This Matters

The study's authors noted that the cognitive interference task used was designed to be measure-for-measure analogous to a human cognitive interference task. Several inter-related mechanisms of EMF action were proposed, including increased amyloid-beta clearance from the brains of Alzheimer's disease mice, increased neuronal activity, and increased cerebral blood flow. The researchers noted that despite numerous studies, there is no definitive evidence that high-frequency EMF exposure is a risk to human health.

Exposure Details

SAR
0.25 W/kg
Source/Device
918 MHz Cell Phone
Exposure Duration
1 h/day for 8.5 or 9.5 months

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.25 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 6 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 918 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 918 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

Despite numerous studies, there is no definitive evidence that high-frequency electromagnetic field (EMF) exposure is a risk to human health. To the contrary, this report presents the first evidence that long-term EMF exposure directly associated with cell phone use (918 MHz; 0.25 w/kg) provides cognitive benefits.

Both cognitive-protective and cognitive-enhancing effects of EMF exposure were discovered for both n...

Although caution should be taken in extrapolating these mouse studies to humans, we conclude that EMF exposure may represent a non-invasive, non-pharmacologic therapeutic against Alzheimer's disease and an effective memory-enhancing approach in general

Cite This Study
Arendash GW, Sanchez-Ramos J, Mori T, Mamcarz M, Lin X, Runfeldt M, Wang L, Zhang G, Sava V, Tan J, Cao C (2010). Electromagnetic Field Treatment Protects Against and Reverses Cognitive Impairment in Alzheimer's Disease Mice J Alzheimers Dis. 19(1):191-210, 2010.
Show BibTeX
@article{gw_2010_electromagnetic_field_treatment_protects_64,
  author = {Arendash GW and Sanchez-Ramos J and Mori T and Mamcarz M and Lin X and Runfeldt M and Wang L and Zhang G and Sava V and Tan J and Cao C},
  title = {Electromagnetic Field Treatment Protects Against and Reverses Cognitive Impairment in Alzheimer's Disease Mice},
  year = {2010},
  
  url = {https://content.iospress.com/articles/journal-of-alzheimers-disease/jad01228},
}

Quick Questions About This Study

The study used both normal mice and transgenic mice destined to develop Alzheimer's-like cognitive impairment.
The exposure was at 918 MHz and 0.25 w/kg.
Long-term EMF exposure reduced brain amyloid-beta deposition through anti-aggregation actions and increased brain temperature during exposure periods.
The researchers urged caution in extrapolating these mouse study results to humans.
The researchers suggested EMF exposure may represent a non-invasive, non-pharmacologic therapeutic against Alzheimer's disease and an effective memory-enhancing approach in general.