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Opioid receptor subtypes that mediate a microwave-induced decrease in central cholinergic activity in the rat.

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Lai H, Carino MA, Horita A, Guy AW, · 1992

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All three opioid receptor subtypes were involved in the microwave-induced decrease in cholinergic activity in the hippocampus, but the decrease in the frontal cortex was not significantly affected by any drug treatment.

Plain English Summary

Summary written for general audiences

Researchers investigated which opioid receptor subtypes mediate a microwave-induced decrease in central cholinergic activity in rats. Rats were pretreated with specific antagonists of mu, delta, and kappa opioid receptors before exposure to microwaves. All three receptor subtypes were involved in the decrease in cholinergic activity in the hippocampus.

Why This Matters

The microwave exposure used a 45-minute pulsed signal at 2,450 MHz with an average power density of 1 mW/cm2 and a whole-body SAR of 0.6 W/kg. The decrease in cholinergic activity in the frontal cortex was not significantly affected by any drug treatment, confirming it is not mediated by endogenous opioids.

Exposure Details

SAR
0.6 W/kg
Power Density
1 mW/cm²
Source/Device
2450 MHz
Exposure Duration
45 min

Exposure Context

This study used 1 mW/cm² for radio frequency:

This study used 0.6 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1 mW/cm²Extreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²Effects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The aim of this study is to investigate Opioid receptor subtypes that mediate a microwave-induced decrease in central cholinergic activity in the rat.

We performed experiments to investigate subtypes of opioid receptors in the brain involved in the ef...

The data showed that all three subtypes of opioid receptors are involved in the microwave-induced de...

Cite This Study
Lai H, Carino MA, Horita A, Guy AW, (1992). Opioid receptor subtypes that mediate a microwave-induced decrease in central cholinergic activity in the rat. Bioelectromagnetics 13(3):237-246, 1992.
Show BibTeX
@article{h_1992_opioid_receptor_subtypes_that_1135,
  author = {Lai H and Carino MA and Horita A and Guy AW and},
  title = {Opioid receptor subtypes that mediate a microwave-induced decrease in central cholinergic activity in the rat.},
  year = {1992},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/1317177/},
}
PubMed: 1317177

Cited By (53 papers)

View all 53 citing papers on Semantic Scholar

Quick Questions About This Study

The aim was to investigate opioid receptor subtypes that mediate a microwave-induced decrease in central cholinergic activity in the rat.
The exposure was acute (45 min) pulsed microwave at 2,450 MHz with 2-microsecond pulses at 500 pps, average power density 1 mW/cm2, peak power density 1 W/cm2, and average whole-body SAR 0.6 W/kg.
All three subtypes of opioid receptors (mu, delta, and kappa) were involved in the microwave-induced decrease in cholinergic activity in the hippocampus.
The microwave-induced decrease in cholinergic activity in the frontal cortex was not significantly affected by any drug treatment, confirming it is not mediated by endogenous opioids.
Rats were pretreated by microinjection of specific antagonists of mu, delta, and kappa opioid receptors into the lateral cerebroventricle before exposure.