Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic activity in the rat.
Lai H, Carino MA, Horita A, Guy AW, · 1994
View Original AbstractAcute 45-minute exposure to pulsed 2450-MHz microwaves decreased hippocampal cholinergic activity in rats, and septal microinjection of beta-funaltrexamine blocked this decrease.
Plain English Summary
Researchers exposed rats to pulsed 2450-MHz microwaves for 45 minutes at a power density of 1 mW/cm2 with a whole body specific absorption rate of 0.6 W/kg. This exposure decreased cholinergic activity in the hippocampus as measured by sodium-dependent high-affinity choline uptake. Microinjection of beta-funaltrexamine (1 microgram) into the septum before exposure blocked the microwave-induced decrease.
Why This Matters
The authors concluded that mu-opioid receptors in the septum mediate the microwave-induced decrease in hippocampal cholinergic activity. They also stated that the findings support the hypothesis that microwaves at a whole body SAR of 0.6 W/kg can activate endogenous opioids in the brain.
Exposure Details
- SAR
- 0.6 W/kg
- Power Density
- 1 mW/cm²
- Source/Device
- 2450 MHz
- Exposure Duration
- 45 min
Exposure Context
This study used 1 mW/cm² for radio frequency:
- 100Mx above the Building Biology guideline of 0.1 μW/m²
- 1.7Mx above the BioInitiative Report recommendation of 0.0006 μW/cm²
This study used 0.6 W/kg for SAR (device absorption):
- 1.5x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The aim of this study is to observe Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic activity in the rat.
Acute (45 min) exposure to pulsed (2 microseconds pulse width, 500 pulses per second) 2450-MHz micro...
These data indicate that mu-opioid receptors in the septum mediate a microwave-induced decrease in cholinergic activity in the hippocampus and support our hypothesis that microwaves at a whole body SAR of 0.6 W/kg can activate endogenous opioids in the brain.
Show BibTeX
@article{h_1994_intraseptal_microinjection_of_betafunaltrexamine_1137,
author = {Lai H and Carino MA and Horita A and Guy AW and},
title = {Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic activity in the rat.},
year = {1994},
url = {https://pubmed.ncbi.nlm.nih.gov/8866962/},
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