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Effects on g2/m phase cell cycle distribution and aneuploidy formation of exposure to a 60 Hz electromagnetic field in combination with ionizing radiation or hydrogen peroxide in l132 nontumorigenic human lung epithelial cells.

No Effects Found

Jin H, Yoon HE, Lee JS, Kim JK, Myung SH, Lee YS. · 2015

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60 Hz magnetic fields up to 2 mT caused no genetic damage and didn't amplify harm from radiation or oxidative stress in human lung cells.

Plain English Summary

Summary written for general audiences

Researchers exposed human lung cells to 60 Hz magnetic fields (1-2 mT) alone and combined with radiation or hydrogen peroxide to test whether EMFs might make cells more vulnerable to genetic damage. The magnetic fields alone caused no genetic damage, and they didn't make the cells more susceptible to damage when combined with other stressors. This suggests that power frequency magnetic fields at these levels don't compromise cellular genetic stability.

Study Details

The aim of the present study was to assess whether exposure to the combination of an extremely low frequency magnetic field (ELF-MF; 60 Hz, 1 mT or 2 mT) with a stress factor, such as ionizing radiation (IR) or H2O2, results in genomic instability in non-tumorigenic human lung epithelial L132 cells.

To this end, the percentages of G2/M-arrested cells and aneuploid cells were examined.

Exposure to 0.5 Gy IR or 0.05 mM H2O2 for 9 h resulted in the highest levels of aneuploidy; however,...

These results suggest that ELF-MFs alone do not induce either G2/M arrest or aneuploidy, even when administered in combination with different stressors.

Cite This Study
Jin H, Yoon HE, Lee JS, Kim JK, Myung SH, Lee YS. (2015). Effects on g2/m phase cell cycle distribution and aneuploidy formation of exposure to a 60 Hz electromagnetic field in combination with ionizing radiation or hydrogen peroxide in l132 nontumorigenic human lung epithelial cells. Korean J Physiol Pharmacol. 19(2):119-124, 2015.
Show BibTeX
@article{h_2015_effects_on_g2m_phase_2849,
  author = {Jin H and Yoon HE and Lee JS and Kim JK and Myung SH and Lee YS.},
  title = {Effects on g2/m phase cell cycle distribution and aneuploidy formation of exposure to a 60 Hz electromagnetic field in combination with ionizing radiation or hydrogen peroxide in l132 nontumorigenic human lung epithelial cells.},
  year = {2015},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/25729273/},
}

Quick Questions About This Study

Researchers exposed human lung cells to 60 Hz magnetic fields (1-2 mT) alone and combined with radiation or hydrogen peroxide to test whether EMFs might make cells more vulnerable to genetic damage. The magnetic fields alone caused no genetic damage, and they didn't make the cells more susceptible to damage when combined with other stressors. This suggests that power frequency magnetic fields at these levels don't compromise cellular genetic stability.