Inhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells. FEBS Lett
Hambarde S, Pandey A, Baskin DS, Helekar SA · 2026
A spinning oscillating magnetic field from a new Oncomagnetic device selectively kills glioblastoma and diffuse intrinsic pontine glioma cells by persistently inhibiting mitochondrial complex I.
Plain English Summary
The authors report results in cultured glioma cells and in a syngeneic mouse model. The spinning oscillating magnetic field caused reactive oxygen species-dependent persistent inhibition of mitochondrial complex I. Steps downstream of this mechanism involve the production of oxidative stress, DNA damage, G1 phase cell cycle arrest, and caspase-dependent apoptosis. The spinning oscillating magnetic field did not produce these effects in normal human astrocytes and astroglial cells.
Why This Matters
The Oncomagnetic device is described as noninvasive and causing selective cytotoxicity in glioblastoma and diffuse intrinsic pontine glioma cells. The authors state that the data provide a rationale for safe clinical use of the Oncomagnetic device.
Show BibTeX
@article{hambarde_s_pandey_a_baskin_ds_helekar_sa_ce4747,
author = {Hambarde S and Pandey A and Baskin DS and Helekar SA},
title = {Inhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells. FEBS Lett},
year = {2026},
doi = {10.1002/1873-3468.70271},
}