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Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines.

No Effects Found

Yoon HE, Lee JS, Myung SH, Lee YS · 2014

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Strong 60-Hz magnetic fields (2,000x household levels) directly damaged DNA and amplified radiation-induced genetic damage in human cells.

Plain English Summary

Summary written for general audiences

Researchers exposed human lung cells to 60-Hz magnetic fields at different strengths and measured DNA damage markers. They found that stronger magnetic fields (2 mT) caused DNA damage on their own and made cells more vulnerable to radiation damage, while weaker fields (1 mT) had no effect. This suggests that power-frequency magnetic fields can damage DNA at high enough levels.

Study Details

Genotoxic effects have been considered the gold standard to determine if an environmental factor is a carcinogen, but the currently available data for extremely low frequency time-varying magnetic fields (ELF-MF) remain controversial. As an environmental stimulus, the effect of ELF-MF on cellular DNA may be subtle. Therefore, a more sensitive method and systematic research strategy are warranted to evaluate genotoxicity.

We investigated the effect of ELF-MF in combination with ionizing radiation (IR) or H2O2 on the DNA ...

Exposure to a 60-Hz, 2 mT ELF-MF for 6 h produced increased γ-H2AX expression, as well as γ-H2AX foc...

ELF-MF could affect the DNA damage response and, in combination with different stimuli, provide different effects on γ-H2AX.

Cite This Study
Yoon HE, Lee JS, Myung SH, Lee YS (2014). Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines. Int J Radiat Biol. 90(4):291-298, 2014.
Show BibTeX
@article{he_2014_increased_h2ax_by_exposure_2862,
  author = {Yoon HE and Lee JS and Myung SH and Lee YS},
  title = {Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines.},
  year = {2014},
  doi = {10.3109/09553002.2014.887866},
  url = {https://www.tandfonline.com/doi/abs/10.3109/09553002.2014.887866},
}

Quick Questions About This Study

Researchers exposed human lung cells to 60-Hz magnetic fields at different strengths and measured DNA damage markers. They found that stronger magnetic fields (2 mT) caused DNA damage on their own and made cells more vulnerable to radiation damage, while weaker fields (1 mT) had no effect. This suggests that power-frequency magnetic fields can damage DNA at high enough levels.