Activation of the TRPV1 Thermoreceptor Induced by Modulated or Unmodulated 1800 MHz Radiofrequency Field Exposure.
Ruigrok HJ, Arnaud-Cormos D, Hurtier A , Poque E, de Gannes FP, Ruffié G, Bonnaudin F, Lagroye I, Sojic N, Arbault S, Lévêque P, Veyret B, Percherancier Y · 2018
View Original AbstractTRPV1 channels were activated by the heat produced by radiofrequency field exposure of transiently-transfected HEK293T cells, but found no evidence of TRPV1 activation in the absence of temperature elevation under radiofrequency field exposure.
Plain English Summary
Researchers monitored TRPV1 activation in real time on live cells using a bioluminescence resonance energy transfer technique. Transiently-transfected HEK293T cells were exposed to 1800 MHz radiofrequency signals including CW, GSM, UMTS, LTE, Wi-Fi and WiMAX at specific absorption rates between 8 and 32 W/kg. TRPV1 channels were activated by the heat produced by radiofrequency exposure, but no activation occurred without temperature elevation. Radiofrequency exposure did not alter the maximal efficacy of capsaicin to activate TRPV1 at fixed temperature.
Why This Matters
The researchers aimed to determine whether TRPV1 can be activated by the heat from radiofrequency fields and by a specific nonthermal interaction. They noted that the existence of nonthermal effects of radiofrequency exposure at environmental levels remains controversial.
Exposure Details
- SAR
- 8 and 32 W/kg
- Source/Device
- 1800 MHz
Exposure Context
This study used 8 and 32 W/kg for SAR (device absorption):
- 20x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The existence of effects of radiofrequency field exposure at environmental levels on living tissues and organisms remains controversial, in particular regarding potential "nonthermal" effects produced in the absence of temperature elevation. Therefore, we investigated whether TRPV1, one of the most studied thermosensitive channels, can be activated by the heat produced by radiofrequency fields and by some specific nonthermal interaction with the fields.
We have recently shown that TRPV1 activation can be assessed in real-time on live cells using the bi...
We showed that, as expected, TRPV1 channels were activated by the heat produced by radiofrequency fi...
Show BibTeX
@article{hj_2018_activation_of_the_trpv1_1302,
author = {Ruigrok HJ and Arnaud-Cormos D and Hurtier A and Poque E and de Gannes FP and Ruffié G and Bonnaudin F and Lagroye I and Sojic N and Arbault S and Lévêque P and Veyret B and Percherancier Y},
title = {Activation of the TRPV1 Thermoreceptor Induced by Modulated or Unmodulated 1800 MHz Radiofrequency Field Exposure.},
year = {2018},
url = {https://pubmed.ncbi.nlm.nih.gov/29059001/},
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