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Brain & Nervous System

Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study.

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Hong I, Garrett A, Maker G, Mullaney I, Rodger J, Etherington SJrkip. · 2018

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Low intensity magnetic stimulation at 1 Hz and 10 Hz depleted selected TCA cycle metabolites in rat neuroblastoma cells, with 1 Hz having stronger effects.

Plain English Summary

Summary written for general audiences

Researchers delivered low intensity repetitive magnetic stimulation (LI-rMS) at 10 mT and at frequencies of 1 Hz and 10 Hz to B50 rat neuroblastoma cells in vitro for 10 minutes. Both frequencies depleted selected tricarboxylic acid (TCA) cycle metabolites without affecting the main energy supplies. The effects were frequency-specific, with 1 Hz stimulation having stronger effects than 10 Hz. The observed depletion of metabolites suggested that higher spontaneous activity may have led to an increase in GABA release.

Why This Matters

This study investigates the behavioural effects of low intensity repetitive magnetic stimulation (LI-rMS) at a cellular and biochemical level. Metabolite levels were measured immediately after stimulation in B50 rat neuroblastoma cells. The researchers noted that the absence of organised neural circuits and other cellular contributors in the B50 cell line limits how far the results can be extrapolated to the human brain. Despite those limits, the researchers stated that the changes provide novel insights into how LI-rMS modulates neural tissue.

Exposure Details

Magnetic Field
10 mT
Source/Device
1 Hz and 10 Hz
Exposure Duration
10 minutes

Exposure Context

This study used 10 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 10 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 50 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1 Hz - 10 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1 Hz - 10 HzPower lines50/60 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

This study investigates the behavioural effects of low intensity repetitive magnetic stimulation (LI-rMS) at a cellular and biochemical level

We delivered LI-rMS (10 mT) at 1 Hz and 10 Hz to B50 rat neuroblastoma cells in vitro for 10 minutes...

LI-rMS at both frequencies depleted selected tricarboxylic acid (TCA) cycle metabolites without affe...

Cite This Study
Hong I, Garrett A, Maker G, Mullaney I, Rodger J, Etherington SJrkip. (2018). Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study. PeerJ. 2018 Mar 12;6:e4501.
Show BibTeX
@article{i_2018_repetitive_low_intensity_magnetic_653,
  author = {Hong I and Garrett A and Maker G and Mullaney I and Rodger J and Etherington SJrkip.},
  title = {Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study.},
  year = {2018},
  
  url = {https://peerj.com/articles/4501/},
}

Quick Questions About This Study

The study used B50 rat neuroblastoma cells, tested in vitro.
Cells received LI-rMS at 10 mT and at 1 Hz and 10 Hz for 10 minutes.
LI-rMS depleted selected TCA cycle metabolites without affecting the main energy supplies.
The effects were frequency-specific, with 1 Hz stimulation having stronger effects than 10 Hz.
The researchers noted that the absence of organised neural circuits and other cellular contributors in the B50 cell line limits the degree to which the results can be extrapolated to the human brain.