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Generation and propagation of yeast prion [URE3] are elevated under electromagnetic field.

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Lian HY, Lin KW, Yang C, Cai P. · 2017

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Exposure to 2.0 GHz RF-EMF or 50 Hz ELF-EMF increased the de novo generation and propagation of the yeast prion [URE3] in both NT64C and SB34 strains.

Plain English Summary

Summary written for general audiences

Researchers exposed two budding yeast strains, NT64C and SB34, to 2.0 GHz RF-EMF and 50 Hz ELF-EMF. Both RF-EMF and ELF-EMF exposure elevated the de novo generation and propagation of the yeast prion [URE3] in the two strains. The increase grew over time, and ELF-EMF showed a dose-dependent effect. Chaperone transcription and expression (Hsp104, Hsp70-Ssa1/2, Hsp40-Ydj1) did not change significantly after exposure. ROS levels and SOD and CAT activities rose after short-term exposure but not after long-term exposure.

Why This Matters

The authors stated that this work demonstrated for the first time that EMF exposure could elevate the de novo generation and propagation of yeast prions and supports the hypothesis that ROS may play a role in the effects of EMF on protein misfolding. They also suggested that the effects of EMF on protein folding and ROS levels may mediate the broad effects of EMF on cell function.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz - 2 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 Hz - 2 GHzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 2.0 GHz and 50 Hz

Study Details

In this study, we studied the effect of 2.0 GHz radio frequency electromagnetic field (RF-EMF) and 50 Hz extremely low frequency electromagnetic field (ELF-EMF) exposure on prion generation and propagation using two budding yeast strains, NT64C and SB34, as model organisms.

Under exposure to RF-EMF or ELF-EMF, the de novo generation and propagation of yeast prions [URE3] w...

This work demonstrated for the first time that EMF exposure could elevate the de novo generation and propagation of yeast prions and supports the hypothesis that ROS may play a role in the effects of EMF on protein misfolding. The effects of EMF on protein folding and ROS levels may mediate the broad effects of EMF on cell function.

Cite This Study
Lian HY, Lin KW, Yang C, Cai P. (2017). Generation and propagation of yeast prion [URE3] are elevated under electromagnetic field. Cell Stress Chaperones. 2017 Dec 6. doi: 10.1007/s12192-017-0867-9.
Show BibTeX
@article{hy_2017_generation_and_propagation_of_2362,
  author = {Lian HY and Lin KW and Yang C and Cai P.},
  title = {Generation and propagation of yeast prion [URE3] are elevated under electromagnetic field.},
  year = {2017},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/29214607/},
}
PubMed: 29214607

Cited By (11 papers)

Quick Questions About This Study

The study tested 2.0 GHz radio frequency electromagnetic field (RF-EMF) and 50 Hz extremely low frequency electromagnetic field (ELF-EMF).
The study used two budding yeast strains, NT64C and SB34.
Exposure to RF-EMF or ELF-EMF elevated the de novo generation and propagation of [URE3] in both strains.
The transcription and expression levels of Hsp104, Hsp70-Ssa1/2, and Hsp40-Ydj1 were not statistically significantly changed after exposure.
ROS levels and the activities of SOD and CAT were significantly elevated after short-term exposure but not after long-term exposure.