Investigation of the genotoxic effect of microwave irradiation in rat bone marrow cells: in vivo exposure.
Trosic I, Busljeta I, Modlic B. · 2004
View Original AbstractMicrowave exposure produced a transient effect on bone marrow red cell proliferation and sporadic micronucleated immature red cells in rats, but differences were not statistically significant at all time points.
Plain English Summary
Researchers used an erythrocyte micronucleus assay to investigate genetic damage in bone marrow red cells of rats exposed to radiofrequency/microwave radiation. Wistar rats were exposed to a 2.45 GHz continuous field for 2 hours daily, 7 days a week, at a power density of 5–10 mW/cm2, with a whole body average specific absorption rate calculated to be 1.25 ± 0.36 W/kg. Significant differences in polychromatic erythrocytes were found on experimental days 8 and 15, and the frequency of micronucleated polychromatic erythrocytes was also significantly increased on day 15. Comparisons after 2, 8, and 30 irradiation treatments did not reveal statistically significant differences between sham-exposed and treated subgroups.
Why This Matters
The study used a standard in vivo cytogenetic test in which bone marrow smears from rats are examined for micronuclei, small nuclear fragments that can indicate genetic damage. Forty exposed rats were divided into four subgroups irradiated for 4, 16, 30, and 60 hours total, and 24 sham-exposed controls were included. Animals in each treated subgroup were killed on the final day of irradiation, and results were evaluated using non-parametric Mann–Whitney and Kruskal–Wallis tests. The researchers described the overall findings as a transient effect, with the sporadic appearance of micronucleated immature bone marrow red cells under the applied experimental conditions.
Exposure Details
- SAR
- 1.25 ± 0.36 W/kg
- Power Density
- 5 – 10 mW/cm²
- Source/Device
- 2.45 GHz RF/MW
- Exposure Duration
- 2 hours daily ,7 days a week
Exposure Context
This study used 5 – 10 mW/cm² for radio frequency:
- 500Mx above the Building Biology guideline of 0.1 μW/m²
- 8.3Mx above the BioInitiative Report recommendation of 0.0006 μW/cm²
This study used 1.25 ± 0.36 W/kg for SAR (device absorption):
- 3.1x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
To investigate the genotoxic effect of microwave irradiation in rat bone marrow cells by an in vivo mammalian cytogenetic test.
An in vivo mammalian cytogenetic test (the erythrocyte micronucleus assay) was used to investigate t...
In comparison with the sham-exposed subgroups, the findings of polychromatic erythrocytes (PCE) reve...
Under the applied experimental conditions the findings revealed a transient effect on proliferation and maturation of erythropoietc cells in the rat bone marrow and the sporadic appearance of micronucleated immature bone marrow red cells.
Show BibTeX
@article{i_2004_investigation_of_the_genotoxic_42,
author = {Trosic I and Busljeta I and Modlic B.},
title = {Investigation of the genotoxic effect of microwave irradiation in rat bone marrow cells: in vivo exposure.},
year = {2004},
url = {http://mutage.oxfordjournals.org/content/19/5/361.short},
}