Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis.
Manjhi J, Kumar S, Behari J, Mathur R. · 2013
View Original AbstractIn rats with spinal cord injury, chronic ELF magnetic field exposure was effective in attenuating spinal cord injury-induced osteoporosis.
Plain English Summary
Researchers studied whether extremely low frequency (ELF) magnetic field exposure could reduce osteoporosis caused by spinal cord injury in rats. Adult male Wistar rats (n = 24) were equally divided into sham, SCI, and SCI+MF groups. Starting one day after injury, the exposed group received ELF magnetic field at 17.96 micro-Tesla and 50 Hz for two hours per day over eight weeks. Bone mineral content, bone mineral density, and biochemical markers were significantly lower in spinal cord injury rats compared with the sham group, and these decreases were attenuated in the magnetic field-treated group, except for carbon content.
Why This Matters
The study used complete transection of the spinal cord at the thoracic 11 vertebra to create bone loss, while the sham group underwent only laminectomy without transection. Researchers measured tibia and femur for bone mineral content (total calcium, phosphorus, and carbon), bone mineral density, and biochemical markers including osteocalcin, collagen I, and alkaline phosphatase. An electron microscopic study revealed enhancement of microstructural composition and compactness in cortical and trabecular parts of the treated bones. Motor function, measured weekly using the Basso, Beattie, and Bresnahan score, decreased after spinal cord injury and partially recovered after ELF magnetic field exposure.
Exposure Details
- Magnetic Field
- 0.01796 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 2 h/d for 8 wk
Exposure Context
This study used 0.01796 mT for magnetic fields:
- 898x above the Building Biology guideline of 0.2 mG
- 179.6x above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The present study was designed to investigate the effect of extremely low frequency (ELF) magnetic field (MF) on spinal cord injury (SCI)-induced osteoporosis in rats.
Adult male Wistar rats (n = 24) were equally divided into sham, SCI, and SCI+MF groups. Complete tra...
The BBB score decreased post-SCI, which partially recovered after ELF-MF. In SCI rats, there was a s...
The results suggest that the chronic (2 h/d ?? 8 wk) ELF-MF exposure (17.96 micro-Tesla, 50 Hz) to SCI rats is effective in attenuating SCI-induced osteoporosis.
Show BibTeX
@article{j_2013_effect_of_extremely_low_280,
author = {Manjhi J and Kumar S and Behari J and Mathur R.},
title = {Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis.},
year = {2013},
url = {https://www.rehab.research.va.gov/jour/2013/501/manjhi501.html},
}