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Nitric oxide modulates the responses of osteoclast formation to static magnetic fields

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Zhang J, Ding C, Meng X, Shang P · 2018

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Static magnetic fields altered osteoclast formation in a way that appears to be mediated by nitric oxide.

Plain English Summary

Summary written for general audiences

Researchers studied whether nitric oxide modulates the responses of osteoclast formation to static magnetic fields. Field strengths of 500 nT (hypomagnetic field), 0.2 T (moderate static magnetic field), and 16 T (high static magnetic field) were utilized as treatment. At 16 T, osteoclast formation was markedly decreased and nitric oxide synthase activity was enhanced, producing a high level of NO. At 500 nT and 0.2 T, osteoclast formation increased alongside decreased NOS activity and NO production.

Why This Matters

When NO production was inhibited with the NOS inhibitor L-NAME, osteoclast formation was restored to control group level in a concentration-dependent manner. Conversely, when NO levels were raised at 500 nT or 0.2 T using the NOS substrate L-Arginine or the NO donor sodium nitroprusside, osteoclast differentiation was inhibited in a concentration-dependent manner. These findings indicate that NO mediates the regulatory role of static magnetic fields on osteoclast formation.

Exposure Details

Magnetic Field
0.0005, 200, 16000 mT

Exposure Context

This study used 0.0005, 200, 16000 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.0005, 200, 16000 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)FCC limit is 400 times higher than this level

Study Details

To study whether Nitric oxide modulates the responses of osteoclast formation to static magnetic fields.

In this study, 500 nT of hypomagnetic field (HyMF), 0.2 T of moderate SMF (MMF) and 16 T of high SM...

Under 16 T, osteoclast formation was markedly decreased with enhanced NO synthase (NOS) activity, th...

Cite This Study
Zhang J, Ding C, Meng X, Shang P (2018). Nitric oxide modulates the responses of osteoclast formation to static magnetic fields Electromagn Biol Med. 37(1):23-34, 2018.
Show BibTeX
@article{j_2018_nitric_oxide_modulates_the_490,
  author = {Zhang J and Ding C and Meng X and Shang P},
  title = {Nitric oxide modulates the responses of osteoclast formation to static magnetic fields},
  year = {2018},
  doi = {10.1080/15368378.2017.1414057},
  url = {https://www.tandfonline.com/doi/abs/10.1080/15368378.2017.1414057},
}
DOI: 10.1080/15368378.2017.1414057

Cited By (16 papers)

View all 16 citing papers on Semantic Scholar

Quick Questions About This Study

The study used 500 nT (hypomagnetic field), 0.2 T (moderate static magnetic field), and 16 T (high static magnetic field).
At 16 T, osteoclast formation was markedly decreased, with enhanced NO synthase activity and a high level of NO produced.
At 500 nT and 0.2 T, osteoclast formation increased, alongside decreased NOS activity and NO production.
The findings indicate that NO mediates the regulatory role of static magnetic fields on osteoclast formation.
When NO production was inhibited with L-NAME, osteoclast formation was restored to control group level in a concentration-dependent manner.