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On the mechanism of the cell cycle control of suspension-cultured tobacco cells after exposure to static magnetic field.

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Mohammadi F, Ghanati F, Sharifi M, Chashmi NA · 2018

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Exposure to a static magnetic field delayed cell cycle progression in cultured tobacco cells and altered levels of several signaling molecules.

Plain English Summary

Summary written for general audiences

Exposure to the static magnetic field delayed the G1 to S transition in the cell cycle, accompanied by a decrease in cyclin-dependent kinase A and D-type cyclin. The static magnetic field also increased levels of nitric oxide, hydrogen peroxide, and salicylic acid compared to the control group.

Why This Matters

The progression of different cell cycle phases was monitored through flow cytometry in a time course manner. Alongside the decrease in CDK A and D-type cyclin, the researchers observed increases in adenylyl cyclase, transcription factor E2F, retinoblastoma protein, and CDK-inhibitor protein 21 transcript accumulation. The results suggest a signaling pathway triggered by the static magnetic field starting from accumulation of nitric oxide and hydrogen peroxide, followed by downstream events including the increase of cyclic nucleotides and subsequent decrease of both CDK A and D-type cyclin.

Exposure Details

Magnetic Field
0.2 mT
Exposure Duration
24 h

Exposure Context

This study used 0.2 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.2 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit

Study Details

To study on the mechanism of the cell cycle control of suspension-cultured tobacco cells after exposure to static magnetic field

Suspension of cultured tobacco cells (Nicotiana tabacum cv. Barley 21) were synchronized via sucrose...

Exposure to SMF delayed G1.S transition which was accompanied by decrease of cyclin-dependent kinas...

The results suggest a signaling pathway triggered by SMF starting from accumulation of NO and H2O2 followed by downstream events including the increase of cyclic nucleotides and subsequent decrease of both CDKA and CycD.

Cite This Study
Mohammadi F, Ghanati F, Sharifi M, Chashmi NA (2018). On the mechanism of the cell cycle control of suspension-cultured tobacco cells after exposure to static magnetic field. Plant Sci. 277:139-144. 2018.
Show BibTeX
@article{f_2018_on_the_mechanism_of_428,
  author = {Mohammadi F and Ghanati F and Sharifi M and Chashmi NA},
  title = {On the mechanism of the cell cycle control of suspension-cultured tobacco cells after exposure to static magnetic field.},
  year = {2018},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0168945218306113},
}

Quick Questions About This Study

The cells were exposed to 0.2 m T SMF up to 24 h.
Exposure to the static magnetic field delayed the G1 to S transition, accompanied by a decrease in cyclin-dependent kinase A and D-type cyclin.
Exposure increased the contents of nitric oxide, hydrogen peroxide, and salicylic acid compared to the control group.
The results suggest a signaling pathway triggered by the static magnetic field starting from accumulation of nitric oxide and hydrogen peroxide, followed by downstream events including the increase of cyclic nucleotides and subsequent decrease of both CDK A and D-type cyclin.