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DNA & Genetic Damage

Effect of radiofrequency radiation on mRNA expression in cultured rodent cells.

No Effects Found

Parker JE, Kiel JL, Winters WD · 1988

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Exposure to 2450 MHz microwave radiation produced no significant differences in mRNA expression in four rodent cell lines.

Plain English Summary

Summary written for general audiences

Researchers exposed four rodent cell lines to 2450 MHz microwave radiation at a Specific Absorption Rate of 103.5 +/- 4.2 W/kg at temperatures of 37, 40, 42, and 45 degrees C. The researchers extracted mRNA from exposed and sham-exposed cells and used DNA probes of oncogenes, heat shock protein, or long terminal repeat sequences to look for differences in mRNA expression. With the cell lines and probes used, no significant differences in mRNA expression were observed after microwave exposure.

Why This Matters

Probes targeting oncogenes, heat shock protein, and long terminal repeat sequences were used to detect changes in mRNA expression levels. The researchers noted that the null result applied specifically to the cell lines and probes used in this study.

Exposure Details

SAR
103.5 +/- 4.2 W/kg
Source/Device
2450 MHz

Exposure Context

This study used 103.5 +/- 4.2 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 103.5 +/- 4.2 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 3 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

To study the effect of radiofrequency radiation on mRNA expression in cultured rodent cells

Four rodent cell lines were exposed to 2450 MHz microwave radiation at a Specific Absorption Rate (S...

With the cell lines and probes used in this study no significant differences in mRNA expression were...

Cite This Study
Parker JE, Kiel JL, Winters WD (1988). Effect of radiofrequency radiation on mRNA expression in cultured rodent cells. Physiol Chem Phys Med NMR 20(2):129-134, 1988. .
Show BibTeX
@article{je_1988_effect_of_radiofrequency_radiation_3298,
  author = {Parker JE and Kiel JL and Winters WD},
  title = {Effect of radiofrequency radiation on mRNA expression in cultured rodent cells.},
  year = {1988},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/3222348/},
}
PubMed: 3222348

Cited By (10 papers)

Quick Questions About This Study

The cells were exposed to 2450 MHz microwave radiation at a SAR of 103.5 +/- 4.2 W/kg.
No significant differences in mRNA expression were observed after microwave exposure.
Cells were exposed at 37, 40, 42, and 45 degrees C.
Radioisotope labelled DNA probes of oncogenes, heat shock protein, or long terminal repeat sequences were used.