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Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain.

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Finnie JW, Blumbergs PC, Manavis J, Utteridge TD, Gebski V, Davies RA, Vernon-Roberts B, Kuchel TR. · 2002

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Long-term GSM radiofrequency field exposure produced negligible disruption to blood-brain barrier integrity in mice.

Plain English Summary

Summary written for general audiences

The study was designed to examine the effect of long-term exposure to global system for mobile communication (GSM) radiofrequency fields on vascular permeability in murine brains. Mice were given a 60-minute far-field, whole body exposure on each of 5 days per week for 104 weeks at specific absorption rates (SAR) of 0.25, 1.0,2.0 and 4.0 W/kg. In all exposed and control groups, albumin extravasation was minimal and was deemed insignificant.

Why This Matters

Control mice were sham-exposed or permitted free movement in a cage to evaluate any stress-related effects. Albumin immunohistochemistry was used to detect increased vascular permeability, with endogenous albumin serving as a vascular tracer. The efficacy of the vascular tracer was confirmed with a positive control group exposed to a clostridial toxin known to increase vascular permeability in the brain. The results suggest that prolonged exposure to mobile telephone-type radiation produces negligible disruption to blood-brain barrier integrity at the light microscope level.

Exposure Details

SAR
0.25, 1, 2, and 4 W/kg
Source/Device
900 MHz
Exposure Duration
60-minute far-field, whole body exposure on each of 5 days per week for 104 weeks

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.25, 1, 2, and 4 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 6 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

To study the effect of long-term exposure to global system for mobile communication (GSM) radiofrequency fields on vascular permeability in murine brains.

Using a purpose-designed exposure system at 900 MHz, mice were given a 60-minute far-field, whole bo...

In all exposed and control groups, albumin extravasation was minimal, often leptomeningeal, and was ...

These results suggest that prolonged exposure to mobile telephone-type radiation produces negligible disruption to blood-brain barrier integrity at the light microscope level using endogenous albumin as a vascular tracer.

Cite This Study
Finnie JW, Blumbergs PC, Manavis J, Utteridge TD, Gebski V, Davies RA, Vernon-Roberts B, Kuchel TR. (2002). Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain. Pathology 34(4):344-347, 2002.
Show BibTeX
@article{jw_2002_effect_of_longterm_mobile_974,
  author = {Finnie JW and Blumbergs PC and Manavis J and Utteridge TD and Gebski V and Davies RA and Vernon-Roberts B and Kuchel TR.},
  title = {Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain.},
  year = {2002},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/12190293/},
}
PubMed: 12190293

Cited By (67 papers)

View all 67 citing papers on Semantic Scholar

Quick Questions About This Study

Mice were given a 60-minute far-field, whole body exposure on each of 5 days per week for 104 weeks at specific absorption rates (SAR) of 0.25, 1.0,2.0 and 4.0 W/kg.
Albumin immunohistochemistry was used to detect increased vascular permeability, using endogenous albumin as a vascular tracer.
Albumin extravasation was minimal and deemed insignificant, with a maximum of three capillaries or venules in a given brain showing leakage.
The results suggest that prolonged exposure to mobile telephone-type radiation produces negligible disruption to blood-brain barrier integrity at the light microscope level.
Control mice were sham-exposed or permitted free movement in a cage to evaluate any stress-related effects.