Effect of Low-Intensity Microwave Radiation on Monoamine Neurotransmitters and Their Key Regulating Enzymes in Rat Brain.
Megha K, Deshmukh PS, Ravi AK, Tripathi AK, Abegaonkar MP, Banerjee BD · 2015
View Original AbstractMicrowave-exposed rats showed significant reductions in dopamine, norepinephrine, epinephrine, and serotonin in the hippocampus, along with downregulated gene expression of key regulating enzymes.
Plain English Summary
Researchers exposed Fischer rats to 900 MHz and 1800 MHz microwave radiation for 30 days at 2 hours per day, 5 days per week, with specific absorption rates of 5.953 × 10−4 and 5.835 × 10−4 W/kg respectively. Levels of dopamine, norepinephrine, epinephrine, and serotonin were measured in the hippocampus using LC–MS/MS. Exposed animals showed significant reductions in DA, NE, E and 5-HT, and significant downregulation in mRNA expression of TH, TPH1, and TPH2 compared with sham-exposed animals (p < 0.05).
Why This Matters
The study measured neurotransmitter levels at both the protein level and at the mRNA level of the enzymes that produce them. Tyrosine hydroxylase regulates dopamine, norepinephrine, and epinephrine, while tryptophan hydroxylase (TPH1 and TPH2) regulates serotonin. The results indicate that low-intensity microwave radiation may cause learning and memory disturbances by altering levels of brain monoamine neurotransmitters at mRNA and protein levels.
Exposure Details
- SAR
- 0.0005953 & 0.0005835 W/kg
- Source/Device
- 900 MHz and 1800 MHz
- Exposure Duration
- 30 days (2 h/day, 5 days/week)
Where This Falls on the Concern Scale
Study Details
The aim of the study was to demonstrate the effect of low-intensity microwave radiation on levels of monoamine neurotransmitters and gene expression of their key regulating enzymes in brain of Fischer rats.
Animals were exposed to 900 MHz and 1800 MHz microwave radiation for 30 days (2 h/day, 5 days/week) ...
Results showed significant reduction in levels of DA, NE, E and 5-HT in hippocampus of microwave-exp...
In conclusion, the results indicate that low-intensity microwave radiation may cause learning and memory disturbances by altering levels of brain monoamine neurotransmitters at mRNA and protein levels.
Show BibTeX
@article{k_2015_effect_of_lowintensity_microwave_145,
author = {Megha K and Deshmukh PS and Ravi AK and Tripathi AK and Abegaonkar MP and Banerjee BD},
title = {Effect of Low-Intensity Microwave Radiation on Monoamine Neurotransmitters and Their Key Regulating Enzymes in Rat Brain.},
year = {2015},
doi = {10.1007/s12013-015-0576-x},
url = {https://link.springer.com/article/10.1007/s12013-015-0576-x},
}