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Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.

Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in neuronal cells.

No Effects Found

Kang KA, Lee HC, Lee JJ, Hong MN, Park MJ, Lee YS, Choi HD, Kim N, Ko YK, Lee JS. · 2014

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Combined RF radiation alone or with menadione or hydrogen peroxide did not influence intracellular ROS levels in U87, PC12, or SH-SY5Y neuronal cells.

Plain English Summary

Summary written for general audiences

Researchers exposed U87, PC12, and SH-SY5Y neuronal cells to combined radiofrequency radiation at 837 MHz CDMA and 1950 MHz WCDMA with a specific absorption rate of 2 W/kg each for 2 hours. They also tested co-exposure with hydrogen peroxide or menadione and measured intracellular reactive oxygen species using flow cytometry with a fluorescent probe. Combined RF radiation alone did not consistently affect ROS levels in a time-dependent manner, and co-exposure with hydrogen peroxide or menadione showed no statistically significant change compared to the chemicals alone.

Why This Matters

The study included incubator control, sham-exposed, and combined RF radiation-exposed groups with or without hydrogen peroxide or menadione. The researchers concluded that combined RF radiation alone or combined with menadione or hydrogen peroxide does not influence intracellular ROS levels in those neuronal cells.

Exposure Details

SAR
2 W/kg
Source/Device
837 MHz CDMA plus 1950 MHz WCDMA
Exposure Duration
continuous for 2 hours

Exposure Context

This study used 2 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 2 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 1 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 837 MHz - 1.95 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 837 MHz - 1.95 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The objective of this study was to investigate the effects of the combined RF radiation (837 MHz CDMA plus 1950 MHz WCDMA) signal on levels of intracellular reactive oxygen species (ROS) in neuronal cells.

Exposure of the combined RF signal was conducted at specific absorption rate values of 2 W/kg of CDM...

Intracellular ROS levels were not consistently affected by combined RF radiation exposure alone in ...

Cite This Study
Kang KA, Lee HC, Lee JJ, Hong MN, Park MJ, Lee YS, Choi HD, Kim N, Ko YK, Lee JS. (2014). Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in neuronal cells. J Radiat Res 2014; 55 (2): 265-276.
Show BibTeX
@article{ka_2014_effects_of_combined_radiofrequency_2767,
  author = {Kang KA and Lee HC and Lee JJ and Hong MN and Park MJ and Lee YS and Choi HD and Kim N and Ko YK and Lee JS.},
  title = {Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in neuronal cells.},
  year = {2014},
  
  url = {https://academic.oup.com/jrr/article/55/2/265/954495?login=true},
}

Quick Questions About This Study

The combined RF signal was delivered at a specific absorption rate of 2 W/kg for CDMA and 2 W/kg for WCDMA for 2 hours.
The study used U87, PC12, and SH-SY5Y neuronal cells.
Combined RF radiation alone did not consistently affect intracellular ROS levels in a time-dependent manner in the tested neuronal cells.
Co-exposure to combined RF radiation with either hydrogen peroxide or menadione showed no statistically significant alteration in ROS levels compared to exposure to the chemicals alone.
Intracellular ROS levels were measured by flow cytometry using the fluorescent probe dichlorofluorescein diacetate.